Haematopoietic Stem Cell Laboratory, The Francis Crick Institute , London, UK.
Department of Life Sciences, Imperial College London, South Kensington campus, London, UK.
Nat Cell Biol. 2020 Jan;22(1):7-17. doi: 10.1038/s41556-019-0444-9. Epub 2020 Jan 6.
Adult haematopoietic stem cells (HSCs) mainly reside in the bone marrow, where stromal and haematopoietic cells regulate their function. The steady state HSC niche has been extensively studied. In this Review, we focus on how bone marrow microenvironment components respond to different insults including inflammation, malignant haematopoiesis and chemotherapy. We highlight common and unique patterns among multiple cell types and their environment and discuss current limitations in our understanding of this complex and dynamic tissue.
成人造血干细胞（HSCs）主要存在于骨髓中，其中基质细胞和造血细胞调节其功能。稳态 HSC 龛位已得到广泛研究。在这篇综述中，我们重点关注骨髓微环境成分如何对包括炎症、恶性造血和化疗在内的不同损伤做出反应。我们强调了多种细胞类型及其环境之间的共同和独特模式，并讨论了我们对这种复杂和动态组织理解的当前局限性。
