Chang Chia-Lin, Huang Kevin Chih-Yang, Chen Tsung-Wei, Chen William Tzu-Liang, Huang Hsuan-Hua, Liu Ya-Ling, Kuo Chia-Hui, Chao K S Clifford, Ke Tao-Wei, Chiang Shu-Fen
Department of Hematology and Oncology, Ministry of Health and Welfare Feng Yuan Hospital, Taichung 42055, Taiwan, R.O.C.
Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung 40402, Taiwan, R.O.C.
Oncol Lett. 2022 May 31;24(1):238. doi: 10.3892/ol.2022.13358. eCollection 2022 Jul.
Rectal adenocarcinoma (READ) constitutes one-third of newly diagnosed colorectal cancer cases. Surgery, chemotherapy and concurrent chemoradiotherapy are the main treatments to improve patient outcomes for READ. However, patients with READ receiving these treatments eventually relapse, leading to a poor survival outcome. The present study collected surgical specimens from patients with READ and determined that cytoplasmic cell division cycle 27 (CDC27) expression was associated with the risk of lymph node metastasis and distant metastasis. Nuclear CDC27 expression was negatively associated with 5-year disease-free survival (DFS) and 5-year overall survival (OS) rates. Multivariate Cox proportional regression analysis showed that nuclear CDC27 was an independent prognostic factor in the patients with READ, especially in those treated with adjuvant chemotherapy. High nuclear CDC27 expression was significantly associated with poorer 5-year DFS (HR, 2.106; 95% CI, 1.275-3.570; P=0.003) and 5-year OS (HR, 2.369; 95% CI, 1.270-4.6810; P=0.005) rates. The data indicated that cytoplasmic CDC27 expression could affect tumor progression and that it plays an important role in metastasis. Nuclear CDC27 expression was markedly associated with poorer survival outcomes and was an independent prognostic factor in patients with postoperative adjuvant chemotherapy-treated READ. Thus, CDC27 expression serves as a potential prognostic marker for rectal tumor progression and chemotherapy treatment.
直肠腺癌（READ）占新诊断结直肠癌病例的三分之一。手术、化疗和同步放化疗是改善READ患者预后的主要治疗方法。然而，接受这些治疗的READ患者最终会复发，导致生存结果不佳。本研究收集了READ患者的手术标本，确定细胞质细胞分裂周期27（CDC27）表达与淋巴结转移和远处转移风险相关。细胞核CDC27表达与5年无病生存率（DFS）和5年总生存率（OS）呈负相关。多因素Cox比例回归分析显示，细胞核CDC27是READ患者的独立预后因素，尤其是在接受辅助化疗的患者中。细胞核CDC27高表达与较差的5年DFS（HR，2.106；95%CI，1.275 - 3.570；P = 0.003）和5年OS（HR，2.369；95%CI，1.270 - 4.6810；P = 0.005）率显著相关。数据表明，细胞质CDC27表达可影响肿瘤进展，且在转移中起重要作用。细胞核CDC27表达与较差的生存结果显著相关，是术后接受辅助化疗的READ患者的独立预后因素。因此，CDC27表达可作为直肠肿瘤进展和化疗治疗的潜在预后标志物。
