Gong Haiyue, He Ping, Lan Xiaozhong, Zeng Lingjiang, Liao Zhihua
School of Life Sciences, Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City and Southwest University, The Provincial and Ministerial Co-founded Collaborative Innovation Center for R&D in Tibet Characteristic Agricultural and Animal Husbandry Resources, Southwest University, Chongqing, China.
Chongqing Academy of Science and Technology, Chongqing, China.
Front Plant Sci. 2022 Jun 2;13:924413. doi: 10.3389/fpls.2022.924413. eCollection 2022.
Hyoscyamine and scopolamine, belonging to medicinal tropane alkaloids (MTAs), are potent anticholinergic drugs. Their industrial production relies on medicinal plants, but the levels of the two alkaloids are very low . Engineering the MTA's production is an everlasting hot topic for pharmaceutical industry. With understanding the MTA's biosynthesis, biotechnological approaches are established to produce hyoscyamine and scopolamine in an efficient manner. Great advances have been obtained in engineering MTA's production . In this review, we summarize the advances on the biosynthesis of MTAs and engineering the MTA's production in hairy root cultures, as well in plants. The problems and perspectives on engineering the MTA's production are also discussed.
莨菪碱和东莨菪碱属于药用托烷生物碱（MTAs），是强效抗胆碱能药物。它们的工业生产依赖于药用植物，但这两种生物碱的含量非常低。工程化生产MTAs一直是制药行业的热门话题。随着对MTAs生物合成的了解，已建立生物技术方法来高效生产莨菪碱和东莨菪碱。在工程化生产MTAs方面已取得了重大进展。在本综述中，我们总结了MTAs生物合成以及在毛状根培养物和植物中工程化生产MTAs的研究进展。还讨论了工程化生产MTAs存在的问题和前景。
