Bertola Laiss, Benseñor Isabela Judith Martins, Brunoni Andre Russowsky, Caramelli Paulo, Barreto Sandhi Maria, Moreno Arlinda Barbosa, Griep Rosane Harter, Viana Maria Carmen, Lotufo Paulo Andrade, Suemoto Claudia Kimie
Universidade de São Paulo, Faculdade de Medicina, São Paulo SP, Brazil.
Universidade de São Paulo, Hospital Universitário, Centro de Pesquisa Epidemiológica e Clínica, São Paulo SP, Brazil.
Dement Neuropsychol. 2022 Apr-Jun;16(2):171-180. doi: 10.1590/1980-5764-DN-2021-0027. Epub 2022 Apr 29.
Repeated cognitive assessment in longitudinal studies favors the occurrence of retest effects, usually increasing the scores obtained at the follow-up assessments when compared to baseline. Therefore, retest effects can compromise the evaluation of cognitive decline in older adults.
We aimed to verify the occurrence of the retest effect and the impact of sociodemographic characteristics on the follow-up scores in a sample of 5,592 participants with a diverse sociodemographic profile, who were assessed twice during 4 years of follow-up.
We tested two possible approaches to correct the retest effect and calculated the Reliable Change Index.
We observed increased scores at the follow-up assessment after 4 years, but the results indicate a modest occurrence of retest effects. The regression difference correction successfully generated follow-up corrected scores, while the mean difference did not provide effective corrections. Sociodemographic characteristics had a minor impact on the retest.
We recommend the regression difference correction for retest effects. The absence of this methodological approach might lead to biased results using longitudinal cognitive scores.
在纵向研究中重复进行认知评估有利于重测效应的出现,与基线相比,通常会提高随访评估时获得的分数。因此,重测效应可能会影响对老年人认知衰退的评估。
我们旨在验证重测效应的出现以及社会人口学特征对5592名具有不同社会人口学特征的参与者随访分数的影响,这些参与者在4年的随访期间接受了两次评估。
我们测试了两种纠正重测效应的可能方法,并计算了可靠变化指数。
我们观察到4年后随访评估时分数有所提高,但结果表明重测效应的出现程度较小。回归差异校正成功生成了随访校正分数,而平均差异未能提供有效的校正。社会人口学特征对重测的影响较小。
我们建议对重测效应采用回归差异校正。缺乏这种方法可能会导致使用纵向认知分数得出有偏差的结果。