Barreto Karollyne Santos, Oliveira Jamary, Reis Luana Dias, Ribeiro Tayane Guimarães, Kauark Roberta Borges Gomes
Universidade Federal da Bahia, Faculdade de Medicina da Bahia, Salvador BA, Brazil.
Complexo Hospitalar Universitário Professor Edgard Santos, Salvador BA, Brazil.
Dement Neuropsychol. 2022 Apr-Jun;16(2):213-219. doi: 10.1590/1980-5764-DN-2021-0056. Epub 2022 Apr 29.
Motor fluctuations in Parkinson's disease (PD) are a frequent long-term complication. Knowledge is limited on the prevalence and incidence of non-motor symptoms (NMS) fluctuations, especially in Brazil.
The objective of this study was to verify the frequency of NMS fluctuations and its relationship with other aspects of PD in patients followed at an outpatient movement disorders clinic.
This is a cross-sectional study in which patients were evaluated for the presence of both types of fluctuations using the Wearing Off Questionnaire (WOQ-19).
A total of 37 patients (11 women and 26 men) were participated in this study, and the frequency of NMS fluctuations was 54.1% (90.9% in women and 38.5% in men). Anxiety was the most frequent non-motor fluctuation (35.1%). The highest percentage of NMS fluctuations (70%) was found in the group in which disease duration was more than 6 years. Most patients with motor fluctuations also had NMS fluctuations (66.7%). No patient presented with isolated NMS fluctuations.
This study showed that, in the study population, approximately half of the patients had NMS fluctuations, with a higher frequency among women. A higher frequency was present in patients with earlier age of diagnosis, longer duration, and greater severity of disease. These findings point to the importance of recognizing the fluctuations of NMS in the study population, since these may not be spontaneously mentioned by the patient, who is remaining unnoticed, undiagnosed, and not treated by the neurologist, representing a significant aggravating factor in the patient's quality of life.
帕金森病（PD）的运动波动是一种常见的长期并发症。关于非运动症状（NMS）波动的患病率和发病率的知识有限，尤其是在巴西。
本研究的目的是在门诊运动障碍诊所随访的患者中，验证NMS波动的频率及其与PD其他方面的关系。
这是一项横断面研究，使用“药效减退问卷（WOQ - 19）”评估患者两种波动的存在情况。
共有37例患者（11例女性和26例男性）参与本研究，NMS波动的频率为54.1%（女性为90.9%，男性为38.5%）。焦虑是最常见的非运动波动（35.1%）。疾病持续时间超过6年的组中NMS波动的比例最高（70%）。大多数有运动波动的患者也有NMS波动（66.7%）。没有患者出现孤立的NMS波动。
本研究表明，在研究人群中，约一半的患者有NMS波动，女性中频率更高。诊断年龄较早、病程较长和疾病严重程度较高的患者中频率更高。这些发现指出了在研究人群中识别NMS波动的重要性，因为患者可能不会自发提及这些波动，从而未被注意、未被诊断且未得到神经科医生的治疗，这是患者生活质量的一个重要加重因素。
