Rodriguez-Blazquez Carmen, Schrag Anette, Rizos Alexandra, Chaudhuri K Ray, Martinez-Martin Pablo, Weintraub Daniel
National Centre of Epidemiology Carlos III Institute of Health Madrid Spain.
Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED) Carlos III Institute of Health Madrid Spain.
Mov Disord Clin Pract. 2020 Dec 21;8(2):231-239. doi: 10.1002/mdc3.13122. eCollection 2021 Feb.
Non-motor symptoms (NMS) are frequent in Parkinson's disease (PD).
To estimate the prevalence of NMS and of non-motor fluctuations (NMF) using the Movement Disorders Society-Non-Motor Rating Scale (MDS-NMS) and other scales assessing NMS, and their relationship with sex and PD severity.
Cross-sectional study with a sample of 402 PD patients. The Hoehn and Yahr staging system (HY), Clinical Impression of Severity Index for PD (CISI-PD), MDS-NMS (including NMF- subscale), Non-Motor Symptoms scale (NMSS), and MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) were applied. A NMS was considered present when scored ≥1. Differences in scores by sex and HY, CISI-PD, and MDS-UPDRS severity levels were calculated using Fisher's exact and chi-squared tests.
Using the MDS-NMS, NMS were present in 99.7% of patients and the mean number of NMS was 16.13 (SD: 9.36). The most prevalent NMS was muscle, joint or back pain (67.4% of the sample) and the least prevalent was dopamine dysregulation syndrome (2.2%). Feeling sad or depressed was significantly more prevalent in women. Using the MDS-NMS revealed more NMS than the other scales assessing NMS. NMF were present in 41% of the sample, with fatigue being the most prevalent symptom (68.5% patients with NMF), and no differences by sex. Patients with greater PD severity had higher prevalence of NMS than patients with lower severity.
Almost all patients with PD experience NMS, and many experience NMF. Prevalence rates for NMS using the MDS-NMS are higher than on other scales used and increase with higher disease severity.
非运动症状（NMS）在帕金森病（PD）中很常见。
使用运动障碍协会非运动症状评定量表（MDS-NMS）和其他评估NMS的量表，估计NMS和非运动波动（NMF）的患病率，以及它们与性别和PD严重程度的关系。
对402例PD患者进行横断面研究。应用Hoehn和Yahr分期系统（HY）、PD严重程度临床印象指数（CISI-PD）、MDS-NMS（包括NMF子量表）、非运动症状量表（NMSS）和MDS统一帕金森病评定量表（MDS-UPDRS）。当评分≥1分时，认为存在NMS。使用Fisher精确检验和卡方检验计算性别、HY、CISI-PD和MDS-UPDRS严重程度水平的评分差异。
使用MDS-NMS，99.7%的患者存在NMS，NMS的平均数量为16.13（标准差：9.36）。最常见的NMS是肌肉、关节或背痛（占样本的67.4%），最不常见的是多巴胺调节障碍综合征（2.2%）。女性中感到悲伤或抑郁的情况明显更普遍。使用MDS-NMS发现的NMS比其他评估NMS的量表更多。41%的样本存在NMF，疲劳是最常见的症状（68.5%的NMF患者），且无性别差异。PD严重程度较高的患者比严重程度较低的患者NMS患病率更高。
几乎所有PD患者都有NMS，许多患者有NMF。使用MDS-NMS的NMS患病率高于其他使用的量表，且随着疾病严重程度的增加而升高。
