Carpi Matteo, Pierantozzi Mariangela, Cofano Stefano, Fernandes Mariana, Cerroni Rocco, De Cillis Francesca, Mercuri Nicola Biagio, Stefani Alessandro, Liguori Claudio
Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Psychology, "Sapienza" University of Rome, 00185 Rome, Italy.
J Pers Med. 2023 Jan 29;13(2):242. doi: 10.3390/jpm13020242.
Non-motor symptoms (NMS) characterize the Parkinson's disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS ( < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task ( < 0.01 and < 0.001), and the latter was also correlated with motor impairment ( < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
非运动症状（NMS）是帕金森病（PD）临床表现的特征之一，除了运动波动外，PD患者还可能经历非运动症状波动（NMF）。这项观察性研究的目的是使用最近验证的非运动波动评估问卷（NoMoFa）调查PD患者中NMS和NMF的存在情况，并评估它们与疾病特征和运动障碍的关联。连续招募PD患者，并对NMS、NMF、运动障碍、运动波动、左旋多巴等效日剂量和运动表现进行评估。该研究纳入的25名患者中有三分之一（10名女性，15名男性，平均年龄：69.9±10.3）出现NMF，出现NMF的患者NMS数量更多（<0.01）。静态NMS和NoMoFa总分与通过全球运动任务评估的运动表现呈正相关（<0.01和<0.001），后者也与运动障碍相关（<0.05），但与运动波动无关。总体而言，这项研究表明，轻度至中度PD患者经常报告NMF，且与NMS数量增加有关。NoMoFa总分与运动功能之间的关系突出了理解NMS和NMF在PD患者管理中的临床作用的重要性。
