Iijima K
Nihon Seikeigeka Gakkai Zasshi. 1987 Jan;61(1):49-62.
Pathogenetic conditions for polydactyly and its pathogenesis were studied by inducing the condition at a high incidence by incubating fertilized ova of white leghorns and locally cauterizing the limb bud with a bipolar microcoagulator. Polydactyly commonly occurred in about 12 hours of the latter half of the third day after cauterization (5 watts) of the preaxial area of the limb bud. This suggests the involvement of space- and time-specificity under the appropriate strength of such stimulation in the pathogenesis of polydactyly. Most polydactyly involved the first toe. Disturbance in the primordium of the metatarsal bone was believed to be related to the pathogenesis. Many reductive complex malformations resembling polydactyly were seen, and the repairing mechanism of these malformations was similar to that of polydactyly. Thus, it seems that the repairing mechanism is oriented to acquiring the proper number of toes and that acquisition of the first toe becomes particularly dominant, resulting in a tendency for polydactyly in the first toe.
通过对白来航鸡受精卵进行孵化并使用双极微型凝固器对肢体芽进行局部烧灼，以高发病率诱导多指畸形的发病情况及其发病机制。多指畸形通常在肢体芽前轴区域烧灼（5瓦）后第三天后半段约12小时出现。这表明在这种刺激的适当强度下，空间和时间特异性参与了多指畸形的发病机制。大多数多指畸形累及第一趾。跖骨原基的紊乱被认为与发病机制有关。观察到许多类似于多指畸形的复杂还原畸形，这些畸形的修复机制与多指畸形相似。因此，似乎修复机制的目标是获得适当数量的脚趾，并且第一趾的获得变得尤为突出，导致第一趾出现多指畸形的倾向。
