Department of Nuclear Medicine, King Hussein Cancer Center (KHCC), Amman, Jordan.
Division of Nuclear Medicine, Department of Radiology and Nuclear Medicine, the University of Jordan, Amman, Jordan.
Front Endocrinol (Lausanne). 2024 Jun 4;15:1366935. doi: 10.3389/fendo.2024.1366935. eCollection 2024.
The incidence of thyroid cancer is on the rise worldwide, with childhood exposure to radiation being the sole acknowledged catalyst for its emergence. Nonetheless, numerous other factors that may pose risks are awaiting thorough examination and validation. This retrospective study aims to explore the malignancies linked to thyroid cancer and contrast the survival rates of those afflicted with a solitary tumor versus those with multiple primary neoplasms (MPN).
This retrospective study examined data from King Hussein Cancer Center (KHCC), Jordan. Among 563 patients diagnosed with thyroid cancer, 30 patients had thyroid malignancy as part of MPN. For a 1:3 propensity score-matched analysis, 90 patients with only a primary thyroid malignancy were also enrolled.
Hematologic and breast malignancies were among the most frequent observed cancers alongside thyroid neoplasm. Patients who had MPN were diagnosed at older age, had higher body mass index and presented with higher thyroglobulin antibody levels ( < 0.05 for each). Additionally, MPN patient displayed a stronger family history for cancers (= 0.002). A median follow-up duration of 135 months unveiled that MPN patients faced a worse 5-year survival compared to their counterparts with a singular neoplasm (87% vs 100% respectively; p < 0.01). However, no distinction emerged in the 5-year event-free survival between these two groups.
MPN correlates with a significantly altered survival outcome of thyroid cancer patients. The diagnosis of thyroid carcinoma at an older age, accompanied by elevated initial thyroglobulin antibody levels and a notable familial predisposition, may raise concerns about the potential occurrence of synchronous or metachronous tumors.
全球范围内，甲状腺癌的发病率呈上升趋势，儿童期接触辐射被认为是其唯一明确的诱发因素。然而，还有许多其他可能存在风险的因素有待深入研究和验证。本回顾性研究旨在探讨与甲状腺癌相关的恶性肿瘤，并对比单发肿瘤与多原发肿瘤（MPN）患者的生存率。
本回顾性研究对约旦侯赛因国王癌症中心（KHCC）的数据进行了分析。在 563 例甲状腺癌患者中，有 30 例甲状腺恶性肿瘤为 MPN 的一部分。为了进行 1:3 倾向评分匹配分析，还纳入了 90 例仅有原发性甲状腺恶性肿瘤的患者。
血液系统和乳腺恶性肿瘤是除甲状腺肿瘤外最常见的合并恶性肿瘤。MPN 患者的诊断年龄较大，身体质量指数较高，且甲状腺球蛋白抗体水平较高（<0.05）。此外，MPN 患者的癌症家族史更为明显（=0.002）。中位随访 135 个月后发现，与单发肿瘤患者相比，MPN 患者的 5 年生存率较差（分别为 87%和 100%；p<0.01）。然而，两组患者的 5 年无事件生存率无差异。
MPN 与甲状腺癌患者的生存结果显著相关。甲状腺癌的诊断年龄较大，伴有初始甲状腺球蛋白抗体水平升高和显著的家族易感性，可能提示存在同时性或异时性肿瘤的潜在发生风险。
