Mala Ali, Khan Yameena Noman, Ahmed Akbar, Khayyam Naema, Aftab Kanwal
Indus Hospital and Health Network, Plot C-76, Sector 31/5, Opposite Darussalam Society Korangi Crossing, Karachi 75190, Pakistan.
Case Rep Hematol. 2022 Jun 8;2022:4353830. doi: 10.1155/2022/4353830. eCollection 2022.
Plasmablastic lymphoma is an aggressive, high-grade non-Hodgkin lymphoma predominantly seen in HIV-infected individuals. Alongside a strong correlation with HIV, PBL can manifest in immunocompromised HIV-negative patients. A rare case of PBL in an immunocompetent and otherwise healthy child presented to Indus Hospital & Health Network (IHHN), Karachi, Pakistan. The patient had complaints of swelling and pain in the right leg and was referred from a city in Interior Sindh. Histopathological analysis revealed sheets and aggregates of neoplasm replacing bone marrow interspersed with sclerotic bony fragments. Large, monomorphic, multinucleated neoplastic cells containing abundant cytoplasm and scattered pleomorphic cells were also noted, leading to the diagnosis of tibial plasmablastic lymphoma. A FAB/LMB96 group C chemotherapy regimen for aggressive and high-risk cancer was administered with a marked improvement in clinical symptoms.
浆母细胞性淋巴瘤是一种侵袭性的高级别非霍奇金淋巴瘤，主要见于感染HIV的个体。除了与HIV有很强的相关性外，浆母细胞性淋巴瘤也可在免疫功能低下的HIV阴性患者中出现。巴基斯坦卡拉奇的印度河医院及健康网络（IHHN）接诊了一例罕见的病例，一名免疫功能正常且其他方面健康的儿童患有浆母细胞性淋巴瘤。该患者主诉右腿肿胀和疼痛，是从信德省内陆的一个城市转诊而来的。组织病理学分析显示肿瘤细胞成片和聚集，取代了骨髓，并夹杂着硬化的骨碎片。还发现了含有丰富细胞质的大的、单形性、多核肿瘤细胞以及散在的多形性细胞，从而诊断为胫骨浆母细胞性淋巴瘤。采用了针对侵袭性和高危癌症的FAB/LMB96 C组化疗方案，临床症状有明显改善。
