Dept of Hematology and Oncology, University of Miami, Sylvester Comprehensive Cancer Center, 1475 NW 12th Ave (D8-4), Miami, FL 33136, USA.
Am J Clin Pathol. 2010 Nov;134(5):710-9. doi: 10.1309/AJCPJH6KEUSECQLU.
Plasmablastic lymphoma (PBL), initially characterized as an aggressive lymphoma arising in the jaw and oral mucosa in HIV-infected patients, was recently reported to occur with extraoral manifestations, heterogeneous histologic findings, and variable association with immunodeficiency states. We reviewed clinical, morphologic, and immunophenotypic features of 13 cases of PBL to determine whether these different subtypes represent distinct morphologic and clinical entities. Two distinct subtypes of PBL were identified and classified as oral and extraoral PBL. The oral PBLs were strongly associated with HIV infection and commonly demonstrated plasmablastic morphologic features without plasmacytic differentiation. Extraoral PBLs tended to occur in patients with underlying non-HIV-related immunosuppression and universally demonstrated plasmacytic differentiation. The patients with oral PBL demonstrated better overall survival compared with patients with extraoral PBL (P = .02). Our findings suggest that PBL with oral and extraoral manifestation represent 2 distinct clinicopathologic entities.
浆母细胞淋巴瘤（PBL）最初被认为是一种在感染 HIV 的患者的颌骨和口腔黏膜中发生的侵袭性淋巴瘤，最近有报道称其也可发生于口腔外部位，具有异质性的组织学表现，并与免疫缺陷状态相关。我们回顾了 13 例 PBL 的临床、形态学和免疫表型特征，以确定这些不同的亚型是否代表不同的形态学和临床实体。我们确定了两种不同的 PBL 亚型，并将其分类为口腔 PBL 和口腔外 PBL。口腔 PBL 与 HIV 感染密切相关，通常表现为浆母细胞形态特征，而无浆细胞分化。口腔外 PBL 倾向于发生在存在非 HIV 相关免疫抑制的患者中，且普遍表现为浆细胞分化。与口腔外 PBL 患者相比，口腔 PBL 患者的总生存率更好（P =.02）。我们的研究结果表明，具有口腔和口腔外表现的 PBL 代表 2 种不同的临床病理实体。
