Hernandez Claudia, Cetner Aaron S, Wiley Elizabeth L
Department of Dermatology (MC 624), University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Pediatr Dermatol. 2009 Nov-Dec;26(6):713-6. doi: 10.1111/j.1525-1470.2009.01019.x.
We present a 14-month-old female child who developed multiple erythematous nodules on her abdomen 5 months after liver and small bowel transplantation. Skin biopsy revealed a dense infiltrate of large cells in the dermal and subcutaneous layers with frequent mitotic figures. The cells were noted to have abundant cytoplasm, prominent nucleoli, and open chromatin. Immunohistochemical stains were positive for CD138, CD56, Ki67 (>90%), and lambda chain restriction. Rare mature B cells (CD20) and rare T cells (CD3) were noted. She was diagnosed with high-grade post-transplant lymphoproliferative disorder most consistent with plasmablastic lymphoma.
我们报告一名14个月大的女童，在肝脏和小肠移植5个月后腹部出现多个红斑性结节。皮肤活检显示真皮层和皮下层有大量大细胞浸润，有频繁的有丝分裂象。这些细胞有丰富的细胞质、明显的核仁及开放染色质。免疫组化染色显示CD138、CD56、Ki67（>90%）及λ链限制性阳性。可见罕见的成熟B细胞（CD20）和罕见的T细胞（CD3）。她被诊断为与浆母细胞淋巴瘤最相符的高级别移植后淋巴增殖性疾病。
