Wu Jiafei, Tang Decai
School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046 Jiangsu, China.
Gastroenterol Res Pract. 2022 Jun 10;2022:9578307. doi: 10.1155/2022/9578307. eCollection 2022.
Colon cancer (CC) is the third most common tumor worldwide. Colon carcinogenesis is strongly linked to inflammation. The initiation and progression of colon cancer may be influenced by epigenetic processes. Cancer metastasis is a multistep process involving several genes and their products. During tumor metastasis, cancer cells first enhance their proliferative capacity by lowering autophagy and apoptosis, and then, their capacity is stimulated by boosting tumors' ability to take nutrients from the outside via angiogenesis. Traditional treatment focuses on eliminating tumor cells by triggering cell death or activating the immune system, which often results in side effects or chemoresistance recurrence. On the contrary, Chinese medicine theory considers the patient's entire inner system and aids in tumor shrinkage while also taking into account the mouse' general health. Because many Chinese herbal medicines (CHM) are consumed as food, using edible CHMs as a diet resource therapy for colon cancer treatment is a viable option. Two traditional Chinese herbs, Astragalus membranaceus and Curcuma zedoaria, are commonly utilized jointly in colon cancer preventive therapy. As a result, the anticancer effect of astragalus and curcumin (AC) on colon cancer suppression in an 18-week AOM-DSS colon cancer mouse model is investigated in this research. These findings may offer a scientific foundation for investigating colon cancer diagnostic biomarkers and therapeutic application of AC in colon cancer treatment. These studies also highlighted the potential effect and mechanism of AC in the treatment of colon cancer, as well as providing insight into how to effectively use it.
结肠癌（CC）是全球第三大常见肿瘤。结肠癌的发生与炎症密切相关。结肠癌的发生和发展可能受表观遗传过程的影响。癌症转移是一个涉及多个基因及其产物的多步骤过程。在肿瘤转移过程中，癌细胞首先通过降低自噬和凋亡来增强其增殖能力，然后通过促进肿瘤通过血管生成从外部获取营养的能力来刺激其能力。传统治疗侧重于通过引发细胞死亡或激活免疫系统来消除肿瘤细胞，这往往会导致副作用或化疗耐药性复发。相反，中医理论考虑患者的整个内部系统，并有助于肿瘤缩小，同时也考虑小鼠的整体健康状况。由于许多中草药（CHM）可作为食物食用，因此将可食用的中草药作为结肠癌治疗的饮食资源疗法是一种可行的选择。两种传统中药黄芪和莪术常用于结肠癌预防治疗。因此，本研究在18周的AOM-DSS结肠癌小鼠模型中研究了黄芪和姜黄素（AC）对结肠癌抑制的抗癌作用。这些发现可能为研究结肠癌诊断生物标志物和AC在结肠癌治疗中的治疗应用提供科学依据。这些研究还强调了AC在治疗结肠癌中的潜在作用和机制，并为如何有效使用它提供了见解。
