• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

指南综述：欧洲肝脏研究学会临床实践指南：药物性肝损伤（DILI）

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI).

作者信息

Brennan Paul N, Cartlidge Peter, Manship Thomas, Dillon John F

机构信息

Centre for Regenerative Medicine, The University of Edinburgh Edinburgh Medical School, Edinburgh, UK.

Molecular and Clinical Medicine, University of Dundee School of Medicine, Dundee, UK.

出版信息

Frontline Gastroenterol. 2021 Jul 29;13(4):332-336. doi: 10.1136/flgastro-2021-101886. eCollection 2022.

DOI:10.1136/flgastro-2021-101886
PMID:35722609
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9186030/
Abstract

The European Association for the Study of the Liver has produced extensive guidelines for the investigation and management of drug-induced liver injury. Here, we provide a commentary and overview of some of the principle disease investigations and management that arise from these guideline recommendations.

摘要

欧洲肝脏研究协会已制定了关于药物性肝损伤调查与管理的详尽指南。在此，我们对这些指南建议中产生的一些主要疾病调查与管理内容进行评论和概述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da9/9186030/fd9ea98dc4ff/flgastro-2021-101886f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da9/9186030/fd9ea98dc4ff/flgastro-2021-101886f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6da9/9186030/fd9ea98dc4ff/flgastro-2021-101886f01.jpg

相似文献

1
Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI).指南综述：欧洲肝脏研究学会临床实践指南：药物性肝损伤（DILI）
Frontline Gastroenterol. 2021 Jul 29;13(4):332-336. doi: 10.1136/flgastro-2021-101886. eCollection 2022.
2
[Several issues worthy of reference and discussion of 2019 edition of the European Association for the Study of the Liver guideline for drug-induced liver injury].[2019年版欧洲肝脏研究协会药物性肝损伤指南中几个值得参考和探讨的问题]
Zhonghua Gan Zang Bing Za Zhi. 2019 Nov 20;27(11):910-912. doi: 10.3760/cma.j.issn.1007-3418.2019.11.018.
3
[EASL clinical practice guidelines recommendations for drug-induced liver injury in 2019].[2019年欧洲肝脏研究学会药物性肝损伤临床实践指南推荐意见]
Zhonghua Gan Zang Bing Za Zhi. 2019 Jun 20;27(6):420-423. doi: 10.3760/cma.j.issn.1007-3418.2019.06.006.
4
Guideline Review: European Association for the Study of Liver (EASL) Clinical Practice Guidelines on Haemochromatosis.指南综述：欧洲肝脏研究协会（EASL）血色病临床实践指南
J Clin Exp Hepatol. 2023 Jul-Aug;13(4):649-655. doi: 10.1016/j.jceh.2022.11.003. Epub 2022 Nov 11.
5
Hepatotoxicity reports in the FDA adverse event reporting system database: A comparison of drugs that cause injury mitochondrial or other mechanisms.美国食品药品监督管理局不良事件报告系统数据库中的肝毒性报告：对导致线粒体损伤或其他机制损伤的药物的比较。
Acta Pharm Sin B. 2021 Dec;11(12):3857-3868. doi: 10.1016/j.apsb.2021.05.028. Epub 2021 Jun 7.
6
Overview on drug-induced liver injury in Brazil.巴西药物性肝损伤概述。
World J Gastrointest Pharmacol Ther. 2021 Sep 5;12(5):100-102. doi: 10.4292/wjgpt.v12.i5.100.
7
Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver.药物性肝损伤：拉丁美洲肝病学会的管理立场文件。
Ann Hepatol. 2021 Sep-Oct;24:100321. doi: 10.1016/j.aohep.2021.100321. Epub 2021 Feb 17.
8
An Update on Drug-induced Liver Injury.药物性肝损伤的最新进展
J Clin Exp Hepatol. 2012 Sep;2(3):247-59. doi: 10.1016/j.jceh.2012.05.002. Epub 2012 Sep 21.
9
Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET].用于评估药物性肝损伤的先进临床前模型——欧洲药物性肝损伤网络[PRO-EURO-DILI-NET]共识声明
J Hepatol. 2021 Oct;75(4):935-959. doi: 10.1016/j.jhep.2021.06.021. Epub 2021 Jun 24.
10
The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond.2015 年及以后诊断和管理药物性肝损伤的艺术与科学。
Clin Gastroenterol Hepatol. 2015 Nov;13(12):2173-89.e8. doi: 10.1016/j.cgh.2015.06.017. Epub 2015 Jun 23.

引用本文的文献

1
Oxidative Ferritin Destruction: A Key Mechanism of Iron Overload in Acetaminophen-Induced Hepatocyte Ferroptosis.氧化型铁蛋白破坏：对乙酰氨基酚诱导的肝细胞铁死亡中铁过载的关键机制
Int J Mol Sci. 2025 Aug 5;26(15):7585. doi: 10.3390/ijms26157585.
2
Advances in mechanistic investigation and treatment of steroid-refractory ICI-induced liver injury.类固醇难治性免疫检查点抑制剂诱导的肝损伤的机制研究与治疗进展
Clin Exp Med. 2025 Aug 11;25(1):288. doi: 10.1007/s10238-025-01721-z.
3
Long-term potassium monitoring and dynamics in risk of liver dysfunction among people living with HIV.

本文引用的文献

1
Herbal and Dietary Supplements-Induced Liver Injury in Latin America: Experience From the LATINDILI Network.拉丁美洲草药和膳食补充剂所致肝损伤：来自LATINDILI网络的经验
Clin Gastroenterol Hepatol. 2022 Mar;20(3):e548-e563. doi: 10.1016/j.cgh.2021.01.011. Epub 2021 Jan 9.
2
AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor Colitis and Hepatitis: Expert Review.AGA 临床实践更新：免疫检查点抑制剂相关性结肠炎和肝炎的诊断与管理：专家综述。
Gastroenterology. 2021 Mar;160(4):1384-1393. doi: 10.1053/j.gastro.2020.08.063. Epub 2020 Oct 17.
3
EASL Clinical Practice Guidelines: Drug-induced liver injury.
HIV感染者肝功能障碍风险中的长期钾监测及动态变化
AIDS Res Ther. 2025 Jul 26;22(1):73. doi: 10.1186/s12981-025-00766-0.
4
Incidence and Predictors of Drug-Induced Liver Injury in Pediatric Tuberculosis Patients Under Anti-tubercular Therapy: A Prospective Observational Study.接受抗结核治疗的儿童结核病患者药物性肝损伤的发生率及预测因素：一项前瞻性观察研究
Cureus. 2025 Jun 9;17(6):e85661. doi: 10.7759/cureus.85661. eCollection 2025 Jun.
5
Evaluation of glutamate dehydrogenase (GLDH) as a diagnostic and prognostic marker in drug-induced liver injury.评估谷氨酸脱氢酶（GLDH）作为药物性肝损伤的诊断和预后标志物。
Prz Gastroenterol. 2025;20(2):165-172. doi: 10.5114/pg.2024.143153. Epub 2024 Sep 23.
6
Multiscale modeling of drug-induced liver injury from organ to lobule.从器官到肝小叶的药物性肝损伤多尺度建模
NPJ Digit Med. 2025 Jun 23;8(1):383. doi: 10.1038/s41746-025-01736-6.
7
Management of drug-induced liver injury associated with anti-cancer therapy.与抗癌治疗相关的药物性肝损伤的管理。
Front Physiol. 2025 Mar 27;16:1541020. doi: 10.3389/fphys.2025.1541020. eCollection 2025.
8
Liver Injury Following Intravenous Methylprednisolone Pulse Therapy in Multiple Sclerosis: The Experience from a Single Academic Liver Center.多发性硬化症患者静脉注射甲基泼尼松龙冲击治疗后的肝损伤：来自单一学术性肝病中心的经验
Biomolecules. 2025 Mar 19;15(3):437. doi: 10.3390/biom15030437.
9
Risk factors for postoperative hypoalbuminemia in ovarian cancer: a predictive nomogram.卵巢癌术后低白蛋白血症的危险因素：一种预测性列线图
BMC Womens Health. 2025 Mar 10;25(1):109. doi: 10.1186/s12905-025-03650-1.
10
Radiological and Pathological Analysis of Pembrolizumab-Associated Lung Lesions: Diagnostic Challenges and Management.帕博利珠单抗相关肺部病变的影像学与病理学分析：诊断挑战与管理
Am J Case Rep. 2025 Jan 8;26:e945022. doi: 10.12659/AJCR.945022.
EASL 临床实践指南：药物性肝损伤。
J Hepatol. 2019 Jun;70(6):1222-1261. doi: 10.1016/j.jhep.2019.02.014. Epub 2019 Mar 27.
4
Risk of hepatotoxicity in cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis of published data.接受免疫检查点抑制剂治疗的癌症患者发生肝毒性的风险：已发表数据的系统评价和荟萃分析。
Int J Cancer. 2017 Sep 1;141(5):1018-1028. doi: 10.1002/ijc.30678. Epub 2017 Jun 20.
5
Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination.抗 CTLA-4 和抗 PD-1 抗体单药及联合治疗的安全性特征。
Nat Rev Clin Oncol. 2016 Aug;13(8):473-86. doi: 10.1038/nrclinonc.2016.58. Epub 2016 May 4.
6
Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study.柏林病例对照监测研究中的草药性肝损伤
Int J Mol Sci. 2016 Jan 15;17(1):114. doi: 10.3390/ijms17010114.
7
Can rechallenge be done safely after mild or moderate drug-induced liver injury?在轻度或中度药物性肝损伤后再次激发用药能否安全进行？
Hepatology. 2016 Mar;63(3):691-3. doi: 10.1002/hep.28353. Epub 2016 Jan 12.
8
Liver injury from herbals and dietary supplements in the U.S. Drug-Induced Liver Injury Network.美国药物性肝损伤网络中来自草药和膳食补充剂的肝损伤
Hepatology. 2014 Oct;60(4):1399-408. doi: 10.1002/hep.27317. Epub 2014 Aug 25.
9
Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland.冰岛普通人群中药物性肝损伤患者的发病情况、临床表现和转归。
Gastroenterology. 2013 Jun;144(7):1419-25, 1425.e1-3; quiz e19-20. doi: 10.1053/j.gastro.2013.02.006. Epub 2013 Feb 16.
10
Rechallenge in drug-induced liver injury: the attractive hazard.药物性肝损伤再挑战：诱人的危险。
Expert Opin Drug Saf. 2009 Nov;8(6):709-14. doi: 10.1517/14740330903397378.