二十二碳六烯酸治疗青少年运动相关性脑震荡的初步随机对照试验。
A Pilot Randomized Controlled Trial of Docosahexaenoic Acid for the Treatment of Sport-Related Concussion in Adolescents.
机构信息
Scottish Rite for Children, Dallas, TX, USA.
University of Texas Southwestern Medical Center, Dallas, TX, USA.
出版信息
Clin Pediatr (Phila). 2022 Nov;61(11):785-794. doi: 10.1177/00099228221101726. Epub 2022 Jun 19.
The objective was to examine the use of docosahexaenoic acid (DHA) for the treatment of sport-related concussion (SRC) in adolescent athletes. We hypothesize that participants who intake 2 g of DHA daily will not experience differences in recovery compared with participants who take a placebo. This double-blind, randomized controlled pilot trial was performed in a tertiary pediatric sports medicine clinic from 2013 to 2017 in adolescents (14-18 years) presenting with diagnosed SRC within 4 days of injury. Forty participants were randomized into DHA or PLACEBO group and were instructed to take 2 capsules twice daily for 12 weeks. Participants in the DHA group were symptom-free earlier than the PLACEBO group (11.0 vs 16.0 days, = .08) and were cleared to begin the Return to Sport progression (14.0 vs 19.5 days, = .12) sooner. The use of 2 g/day of DHA was well-tolerated and did not significantly affect recovery times in adolescent athletes following SRC. ClincalTrials.gov, NCT01903525.
目的是研究二十二碳六烯酸（DHA）在治疗青少年运动员运动相关性脑震荡（SRC）中的作用。我们假设与服用安慰剂的参与者相比，每天摄入 2 克 DHA 的参与者在恢复方面不会有差异。这项双盲、随机对照的初步试验于 2013 年至 2017 年在一家三级儿科运动医学诊所进行，参与者为受伤后 4 天内确诊为 SRC 的青少年（14-18 岁）。40 名参与者被随机分为 DHA 或安慰剂组，并被指示每天服用 2 粒胶囊，持续 12 周。DHA 组的症状缓解时间早于安慰剂组（11.0 天 vs. 16.0 天， =.08），开始重返运动的时间更早（14.0 天 vs. 19.5 天， =.12）。每天使用 2 克 DHA 耐受性良好，不会显著影响 SRC 后青少年运动员的恢复时间。ClinicalTrials.gov，NCT01903525。
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