Tuan R S, Nguyen H Q
J Exp Med. 1987 May 1;165(5):1418-23. doi: 10.1084/jem.165.5.1418.
We have developed an experimental system involving calcium-deficient chick embryos to examine the relationship between calcium homeostasis and cardiovascular activities. We have found that the calcium-deficient embryos, when compared with control animals, exhibit tachycardia and are significantly hypertensive. The effects are unlikely to be due to gross cardiac malformations or hypertrophy. The hypertensive condition appears to be a specific result of the systemic calcium deficiency since calcium supplementation to these embryos significantly restores the functions to normality.
我们开发了一个涉及缺钙鸡胚胎的实验系统，以研究钙稳态与心血管活动之间的关系。我们发现，与对照动物相比，缺钙胚胎表现出心动过速和明显的高血压。这些影响不太可能是由于严重的心脏畸形或肥大。高血压状况似乎是全身性钙缺乏的一个特定结果，因为对这些胚胎补充钙可显著使功能恢复正常。
