The Effect of Extracellular Vesicles from Korean Women in Their 20s on Skin Aging.

Extracellular vesicles, which are highly conserved in most cells, contain biologically active substances. The vesicles and substances interact with cells and impact physiological mechanisms. The skin is the most external organ and is in direct contact with the external environment. Photoaging and skin damage are caused by extrinsic factors. The formation of wrinkles is a major indicator of skin aging and is caused by a decrease in collagen and hyaluronic acid. MMP-1 expression is also increased. Due to accruing damage, skin aging reduces the ability of the skin barrier, thereby lowering the skin's ability to contain water and increasing the amount of water loss. suppresses various harmful bacteria by secreting an antimicrobial substance. is also found in the skin, and research on the interactions between the bacteria and the skin is in progress. Although several studies have investigated , there are only a limited number of studies on extracellular vesicles (EV) derived from , especially in relation to skin aging. Herein, we isolated EVs that were secreted from of women in their 20s (EVs). We then investigated the effect of EVs on skin aging in CCD986sk. We showed that EVs modulated the mRNA expression of ECM related genes in vitro. Furthermore, EVs suppressed wrinkle formation and pigmentation in clinical trials. These results demonstrated that EVs have a great effect on skin aging by regulating ECM related genes. In addition, our study offers important evidence on the depigmentation effect of EVs.