多种途径相互作用生成 DNA 甲基组。

Crosstalk among pathways to generate DNA methylome.

机构信息

Department of Biological Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

出版信息

Curr Opin Plant Biol. 2022 Aug;68:102248. doi: 10.1016/j.pbi.2022.102248. Epub 2022 Jun 17.

DOI:10.1016/j.pbi.2022.102248

Abstract

Cytosine is methylated in both CpG and non-CpG contexts (mCG and mCH, respectively) in plant genomes. Although mCG and mCH are almost independent in regard to their "maintenance," recent studies uncovered crosstalk between them during their "establishment," which unexpectedly functions in both RNAi-dependent and -independent pathways. In addition, the importance of linker histone H1 and variants of histone H2A to DNA methylation dynamics is starting to be understood. We summarize these new aspects of mechanisms to generate DNA methylomes and discuss future prospects.

摘要

在植物基因组中，胞嘧啶在 CpG 和非 CpG 环境中（分别为 mCG 和 mCH）被甲基化。尽管 mCG 和 mCH 在“维持”方面几乎是独立的，但最近的研究揭示了它们在“建立”过程中的相互作用，这一作用出乎意料地在 RNAi 依赖和非依赖途径中都发挥了作用。此外，连接组蛋白 H1 和组蛋白 H2A 变体对 DNA 甲基化动态的重要性开始被理解。我们总结了这些生成 DNA 甲基组学的新机制方面，并讨论了未来的前景。