Department of Psychology, University of Oregon, Eugene, Oregon; Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California.
Department of Psychology, University of Oregon, Eugene, Oregon.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Jan;9(1):41-49. doi: 10.1016/j.bpsc.2022.06.005. Epub 2022 Jun 18.
This study first examined how mothers with and without depression differ in neural activation in response to adolescents' affective faces. Second, it examined the extent to which these neural activation patterns are related to observed positive and aggressive parenting behavior.
Mothers with and without depression (based on self-reported symptoms and treatment history; n = 77 and n = 64, respectively; mean = 40 years) from low-income families completed an interaction task with their adolescents (mean = 12.8 years), which was coded for parents' aggressive and positive affective behavior. During functional magnetic resonance imaging, mothers viewed blurry, happy, sad, and angry faces of unfamiliar adolescents, with an instruction to either label the emotion or determine the clarity of the image.
The depression group showed less activation in the posterior midcingulate than the control subject group while labeling happy faces. Higher activation in the insula and dorsomedial prefrontal cortex (PFC) was related to less positive parenting behavior. Ventrolateral PFC activation was most pronounced when labeling negative emotions, but stronger ventrolateral PFC response to happy faces was associated with more aggressive parenting behavior.
This demonstrates the association between parents' neural responses to adolescent faces and their behavior during interactions with their own adolescents, with relatively low insula and dorsomedial PFC activation supporting positive parenting and affect-dependent response in the ventrolateral PFC as being important to limit aggressive behavior.
本研究首先考察了患有和未患有抑郁症的母亲在对青少年情感面孔的神经激活方面有何不同。其次，它考察了这些神经激活模式与观察到的积极和攻击性行为之间的关系。
来自低收入家庭的患有和未患有抑郁症的母亲（基于自我报告的症状和治疗史；分别为 n=77 和 n=64，平均年龄为 40 岁）与他们的青少年（平均年龄为 12.8 岁）完成了一项互动任务，该任务对父母的攻击性行为和积极情感行为进行了编码。在功能磁共振成像期间，母亲观看了模糊的、快乐的、悲伤的和愤怒的陌生青少年的面孔，并被指示标记情绪或确定图像的清晰度。
在标记快乐面孔时，抑郁组的后中扣带回的激活低于对照组。岛叶和背内侧前额叶皮质（PFC）的较高激活与较少的积极养育行为有关。当标记负面情绪时，腹外侧 PFC 的激活最为明显，但对快乐面孔的腹外侧 PFC 反应越强与更多的攻击性行为有关。
这表明父母对青少年面孔的神经反应与其与自己青少年互动时的行为之间存在关联，相对较低的岛叶和背内侧 PFC 激活支持积极的养育行为和腹外侧 PFC 中的情感依赖反应，这对限制攻击性行为很重要。
