Leppo J A
J Nucl Med. 1987 May;28(5):878-85.
The comparative effects of altered cellular function and coronary perfusion on myocardial 201Tl and 83Rb uptake were evaluated in three groups of isolated rabbit hearts having isovolumic contractions. Paired-indication dilution experiments were performed with 201Tl, 83Rb, and 111In-labeled albumin as an intravascular reference marker. In Group A hearts (n = 12), isotope transport was determined during control, hypoxia, and ischemia. In Group B hearts (n = 8), isotope transport was measured at control flow and again at a 50% and 80% reduction. In Group C hearts (n = 8) only 201Tl uptake was determined at control and following coronary reperfusion. Myocardial 201Tl and 83Rb transport were not significantly different and were proportional to flow. Although all interventions caused significant hemodynamic alterations, neither tracer was affected by hypoxia at constant flow. Thallium-201 permeation, however, was transiently decreased immediately after coronary reperfusion. We conclude that myocardial uptake of 201Tl and 83Rb are similar and directly related to flow, but do not reflect hypoxia induced cellular dysfunction.
在三组进行等容收缩的离体兔心脏中，评估了细胞功能改变和冠状动脉灌注对心肌201Tl和83Rb摄取的比较效应。使用201Tl、83Rb和111In标记的白蛋白作为血管内参考标记物进行配对指示剂稀释实验。在A组心脏（n = 12）中，在对照、缺氧和缺血期间测定同位素转运。在B组心脏（n = 8）中，在对照流量下以及流量降低50%和80%时再次测量同位素转运。在C组心脏（n = 8）中，仅在对照时和冠状动脉再灌注后测定201Tl摄取。心肌201Tl和83Rb转运无显著差异，且与流量成比例。尽管所有干预均引起显著的血流动力学改变，但在恒定流量下，两种示踪剂均不受缺氧影响。然而，冠状动脉再灌注后立即，201Tl的渗透暂时降低。我们得出结论，心肌对201Tl和83Rb的摄取相似且与流量直接相关，但不反映缺氧诱导的细胞功能障碍。
