Marshall R C, Taylor S E, Powers-Risius P, Reutter B W, Kuruc A, Coxson P G, Huesman R H, Budinger T F
E.O. Lawrence Berkeley National Laboratory, Center for Functional Imaging, California 94720, USA.
Am J Physiol. 1997 Mar;272(3 Pt 2):H1480-90. doi: 10.1152/ajpheart.1997.272.3.H1480.
Evaluation of myocardial perfusion with tracers such as thallium and rubidium is based on the assumption that tissue tracer content is proportional to flow. The purpose of this study was to evaluate the relationship between flow and tissue tracer content of 201Tl and 83Rb in the isolated perfused rabbit heart. 83Rb (86-day half-life), an isotope that is not used clinically, was used as a subsitute for 82Rb (76-s half-life) to improve the accuracy and precision of data acquisition. The multiple indicator-dilution technique was employed with two independent computational approaches. The first approach explicitly deconvolved 201Tl and 83Rb venous concentration curves by the intravascular reference tracer curve. The second approach used a conventional analysis. Both approaches showed that there was more early washout of 83Rb than 201Tl and that the heart retained 201Tl better than 83Rb within 2 min after isotope introduction. These data indicate that 201Tl is a better perfusion tracer than 83Rb in the isolated rabbit heart.
使用铊和铷等示踪剂评估心肌灌注是基于组织示踪剂含量与血流量成正比这一假设。本研究的目的是评估在离体灌注兔心脏中201铊和83铷的血流量与组织示踪剂含量之间的关系。83铷（半衰期86天）是一种未用于临床的同位素，被用作82铷（半衰期76秒）的替代物，以提高数据采集的准确性和精确性。采用多指示剂稀释技术和两种独立的计算方法。第一种方法通过血管内参考示踪剂曲线明确反卷积201铊和83铷的静脉浓度曲线。第二种方法采用传统分析。两种方法均显示，83铷比201铊有更多的早期洗脱，且在引入同位素后2分钟内，心脏对201铊的保留优于83铷。这些数据表明，在离体兔心脏中，201铊是比83铷更好的灌注示踪剂。
