Balasubramaniam G S, Hurley J V
J Pathol. 1987 Feb;151(2):139-46. doi: 10.1002/path.1711510207.
Studies by a combination of vascular perfusion, histological and electron microscopic techniques show that subcutaneous injection of air into rats excites no acute inflammatory response, but leads to the formation of a pouch lined by avascular fibrous tissue. Existing subcutaneous blood vessels are displaced by the pouch but no new blood vessels are formed. By contrast injection of carrageenan with the air or into a preformed air pouch leads to a severe inflammatory reaction and the rapid development of a thick layer of granulation tissue. Either type of pouch is a useful system in which to study inflammation. However because the distribution and ultrastructure of small blood vessels in the pouch wall is quite different from the known characteristics of the microcirculation of synovial membrane, the air pouch is an unsuitable model for the study of injury to joints or experimental arthritis.
通过血管灌注、组织学和电子显微镜技术相结合的研究表明，给大鼠皮下注射空气不会引发急性炎症反应，但会导致形成一个由无血管纤维组织衬里的腔袋。现有的皮下血管被腔袋推移，但不会形成新的血管。相比之下，将角叉菜胶与空气一起注射或注射到预先形成的气袋中会导致严重的炎症反应，并迅速形成一层厚厚的肉芽组织。这两种类型的腔袋都是研究炎症的有用系统。然而，由于腔袋壁中小血管的分布和超微结构与滑膜微循环的已知特征有很大不同，气袋不是研究关节损伤或实验性关节炎的合适模型。
