De Brito F B, Moore A R, Adhya S, Al-Duaij A Y, Willoughby D A
Int J Tissue React. 1986;8(4):289-94.
The influence of adjuvant polyarthritis on subcutaneous air pouches in rats was examined in the light of reports of the resemblance of their cavity lining to normal synovium. Marked macroscopic and microscopic changes were observed. These included thickening of air-pouch wall, hyperplasia of lining cells, infiltration of inflammatory cells, fibrosis, and the production of an effusion in the cavity; such changes are comparable to the proliferative synovitis reported in arthritic joints of diseased animals. However, whereas talus and patella cartilage were affected by the disease, these and femoral-head cartilage seemed to be relatively spared when implanted in air pouches of adjuvant-diseased rats even after a massive inflammatory response was elicited in the cavity following challenge with tuberculin. In conclusion, the present study demonstrates the generalized nature of adjuvant disease and confirms the lack of association between inflammation and cartilage destruction.
鉴于有报道称大鼠皮下气囊的腔衬与正常滑膜相似，研究了佐剂性多关节炎对大鼠皮下气囊的影响。观察到明显的宏观和微观变化。这些变化包括气囊壁增厚、衬里细胞增生、炎性细胞浸润、纤维化以及腔内积液；这些变化与患病动物关节炎关节中报道的增殖性滑膜炎相当。然而，虽然距骨和髌骨软骨受疾病影响，但当将这些软骨和股骨头软骨植入佐剂病大鼠的气囊中时，即使在用结核菌素激发后在腔内引发大量炎症反应，它们似乎也相对未受影响。总之，本研究证明了佐剂病的全身性，并证实了炎症与软骨破坏之间缺乏关联。
