Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing, China.
Department of Radiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
CNS Neurosci Ther. 2022 Oct;28(10):1547-1556. doi: 10.1111/cns.13896. Epub 2022 Jun 21.
We aimed to find where and how noise-induced cochlear hearing loss affects the central nervous system during the early state and identify the neural substrate for aberrant patterns that mediating noise-related anxiety-/depression- like behaviors.
Broad band noise with 122 dB for 2 hours was conducted to induce hearing loss. We defined 0 day (N0D) and 10 days (N10D) post noise as the acute and sub-acute period. Behavioral tests (Open field test and light/dark test) and resting-state fMRI were computed to evaluate emotional conditions and aberrant neural activity. Functional connectivity analysis using the anterior cingulate cortex as a seed was computed to reveal the spatial distribution beyond auditory network during both periods.
Anxiety-/depression-like behaviors were found in rats with noise exposure. Between-group analysis revealed that N0D rats displayed widespread reductions in functional connectivity, spanning primary somatosensory cortex, medial geniculate body, inferior colliculus, cingulate cortex, cerebellar lobule comparing with N10D rats and a similar pattern was also occurred in comparison with the control group.
Taken together, an "acoustic-causing" network accounting for distress and gating of noise exposure related anxiety/depression was proposed.
我们旨在探讨噪声诱导的耳蜗听力损失在早期阶段如何影响中枢神经系统，并确定介导与噪声相关的焦虑/抑郁样行为的异常模式的神经基础。
采用 122dB 的宽带噪声刺激 2 小时诱导听力损失。我们将噪声后 0 天（N0D）和 10 天（N10D）定义为急性和亚急性期。进行行为测试（旷场试验和明暗试验）和静息态 fMRI 以评估情绪状况和异常神经活动。使用前扣带皮层作为种子进行功能连接分析，以揭示两个时期听觉网络之外的空间分布。
噪声暴露的大鼠出现焦虑/抑郁样行为。组间分析显示，与 N10D 大鼠相比，N0D 大鼠的功能连接广泛减少，跨越初级体感皮层、内侧膝状体、下丘、扣带回皮层、小脑小叶；与对照组相比，也出现了类似的模式。
总之，提出了一个“声致”网络，用于解释与噪声暴露相关的焦虑/抑郁的痛苦和门控。
