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阿特劳-5BJN(IL18)的基因组序列,一种具有毒力基因敲除的重组结节性皮肤病病毒

Genome Sequence of Atyrau-5BJN(IL18), a Recombinant Lumpy Skin Disease Virus with Knockout of Virulence Genes.

作者信息

Issabek Aisha U, Orynbayev Mukhit B, Sultankulova Kulyaisan T, Amirgazin Asylulan, Zakarya Kunsulu D, Omarova Zamira, Chervyakova Olga V

机构信息

Research Institute for Biological Safety Problems, Gvardeyskiy, Republic of Kazakhstan.

National Center for Biotechnology, Nur-Sultan, Republic of Kazakhstan.

出版信息

Microbiol Resour Announc. 2022 Jul 21;11(7):e0038022. doi: 10.1128/mra.00380-22. Epub 2022 Jun 21.

DOI:10.1128/mra.00380-22
PMID:35727014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9302139/
Abstract

Here, we present the coding sequence of the genome of the recombinant lumpy skin disease virus (LSDV) Atyrau-5BJN(IL18), obtained by knocking out four genes in the genome of a virulent field LSDV isolate. Genome sequencing confirmed the deletion of genes and the insertion of a foreign sequence in the viral genome.

摘要

在此,我们展示了重组牛结节性皮肤病病毒(LSDV)阿特劳 - 5BJN(IL18)的基因组编码序列,该病毒是通过敲除一株强毒力的田间LSDV分离株基因组中的四个基因获得的。基因组测序证实了病毒基因组中基因的缺失和外源序列的插入。

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引用本文的文献

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Lumpy Skin Disease Virus with Four Knocked Out Genes Was Attenuated In Vivo and Protects Cattle from Infection.具有四个基因敲除的结节性皮肤病病毒在体内减毒,并能保护牛免受感染。
Vaccines (Basel). 2022 Oct 12;10(10):1705. doi: 10.3390/vaccines10101705.

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