State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, People's Republicof China.
Org Lett. 2022 Jul 1;24(25):4580-4585. doi: 10.1021/acs.orglett.2c01674. Epub 2022 Jun 21.
Given that biaryl motifs are found in many useful molecules, including pesticides, pharmaceuticals, functional materials, and polymers, the development of methods for their construction is important. Herein, we report a two-step method for C(sp)-H/C(sp)-H cross-coupling reactions to synthesize 2-arylindole derivatives by combining palladium catalysis and photocatalysis. This mild, dual-catalysis method showed good functional group tolerance and a wide substrate scope and could be used for late-stage functionalization of oligopeptides, drugs, and natural products.
鉴于联芳基基序存在于许多有用的分子中，包括杀虫剂、药物、功能材料和聚合物，因此开发它们的构建方法很重要。在此，我们报告了一种两步法 C(sp)-H/C(sp)-H 交叉偶联反应，通过结合钯催化和光催化来合成 2-芳基吲哚衍生物。这种温和的双催化方法显示出良好的官能团耐受性和广泛的底物范围，并可用于寡肽、药物和天然产物的后期官能化。
