钯(0)催化吲哚的去芳构化芳基化反应：方便地获得螺吲哚啉衍生物。
Palladium(0)-catalyzed dearomative arylation of indoles: convenient access to spiroindolenine derivatives.
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.
出版信息
Org Lett. 2012 Jul 20;14(14):3772-5. doi: 10.1021/ol301663h. Epub 2012 Jul 12.
PMID:22783995
Abstract
Dearomatization of an indole via palladium(0)-catalyzed cross-coupling reaction has been realized. With readily available triphenylphosphine as ligand, various spiroindolenine derivatives have been obtained in good to excellent yields, and enantioselective control is also feasible with chiral ligands.
摘要
通过钯（0）催化的交叉偶联反应实现了吲哚的去芳构化。使用易得的三苯基膦作为配体，可以以良好到优异的收率得到各种螺吲哚啉衍生物，并且使用手性配体也可以实现对映选择性控制。
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