Mayo Clinic Alix School of Medicine, Scottsdale, AZ, USA.
Division of Colon and Rectal Surgery, Department of Surgery, Mayo Clinic, Phoenix, AZ, USA.
Am Surg. 2023 Dec;89(12):6197-6199. doi: 10.1177/00031348221109811. Epub 2022 Jun 21.
Extrapulmonary involvement of coronavirus-19 disease (COVID-19) is being documented and studied at an increasing frequency. Specifically, gastrointestinal involvement is hypothesized to occur due to cellular entry via the ACE2 receptor found in gastrointestinal epithelial cells, causing inflammation and symptoms such as abdominal pain, nausea/vomiting, and diarrhea. We present the case of a 45-year-old female with recent severe COVID-19 infection and early gastrointestinal symptoms who later presented with worsening abdominal pain, nausea, vomiting, and constipation after initial discharge. She was diagnosed with a large bowel obstruction and underwent urgent exploratory laparotomy, which revealed a stricture of the distal transverse colon. Following segmental resection, the patient experienced resolution of symptoms. We hypothesize that this patient's colonic stricture arose secondary to severe COVID-19-induced bowel inflammation.
越来越多的研究正在记录和研究 COVID-19 疾病的肺外表现。具体来说，由于冠状病毒通过胃肠道上皮细胞中的 ACE2 受体进入细胞，导致炎症和腹痛、恶心/呕吐和腹泻等症状，因此假设胃肠道受累。我们报告了一例 45 岁女性，近期患有严重 COVID-19 感染和早期胃肠道症状，最初出院后出现腹痛加重、恶心、呕吐和便秘。她被诊断为大肠梗阻，并接受了紧急剖腹探查术，发现横结肠远端狭窄。节段切除后，患者症状缓解。我们假设该患者的结肠狭窄是由严重 COVID-19 引起的肠道炎症引起的。
