Ngai Zi Ni, Chok Kian Chung, Ng Khuen Yen, Koh Rhun Yian, Chye Soi Moi
School of Health Science, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
School of Pharmacy, Monash University Malaysia, Subang Jaya, Selangor, Malaysia.
Horm Mol Biol Clin Investig. 2022 Jun 22;43(4):485-503. doi: 10.1515/hmbci-2022-0018. eCollection 2022 Dec 1.
Lung cancer is the second most common cancer and the most lethal cancer worldwide. Melatonin, an indoleamine produced in the pineal gland, shows anticancer effects on a variety of cancers, especially lung cancer. Herein, we clarify the pathophysiology of lung cancer, the association of circadian rhythm with lung, and the relationship between shift work and the incidence of lung cancer. Special focus is placed on the role of melatonin receptors in lung cancer, the relationship between inflammation and lung cancer, control of cell proliferation, apoptosis, autophagy, and immunomodulation in lung cancer by melatonin. A review of the drug synergy of melatonin with other anticancer drugs suggests its usefulness in combination therapy. In summary, the information compiled may serve as a comprehensive reference for the various mechanisms of action of melatonin against lung cancer, as a guide for the design of future experimental research and for advancing melatonin as a therapeutic agent for lung cancer.
肺癌是全球第二常见且最致命的癌症。褪黑素是松果体分泌的一种吲哚胺，对多种癌症尤其是肺癌具有抗癌作用。在此，我们阐明肺癌的病理生理学、昼夜节律与肺的关联以及轮班工作与肺癌发病率之间的关系。特别关注褪黑素受体在肺癌中的作用、炎症与肺癌的关系、褪黑素对肺癌细胞增殖、凋亡、自噬的调控以及免疫调节作用。对褪黑素与其他抗癌药物的药物协同作用的综述表明其在联合治疗中的有效性。总之，所汇编的信息可作为褪黑素抗肺癌各种作用机制的综合参考，为未来实验研究的设计以及将褪黑素推进为肺癌治疗药物提供指导。
