Department of Biotechnology and Bioinformatics, Korea University, Sejong-Ro 2511, Sejong 30019, Republic of Korea.
Institute of Industrial Technology, Korea University, Sejong-Ro 2511, Sejong 30019, Republic of Korea.
Int J Mol Sci. 2024 Jul 9;25(14):7530. doi: 10.3390/ijms25147530.
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external and internal signs of aging manifest in various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative disorders, and cancer. Additionally, cancer, like aging, is a complex disease that arises from the accumulation of various genetic and epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for aging and cancer development. Natural compounds and herbal medicines have gained significant attention for their potential in preventing age-related diseases and inhibiting cancer progression. These compounds demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, and anti-angiogenic effects as well as circadian clock regulation. This review explores age-related diseases, cancers, and the potential of specific natural compounds in targeting the key features of these conditions.
衰老是一个多方面的过程，受到遗传因素、生活方式和环境因素的影响。随着时间的推移，人体主要功能会发生退行性变化。衰老的外在和内在迹象表现方式多种多样，包括皮肤干燥、皱纹、肌肉骨骼紊乱、心血管疾病、糖尿病、神经退行性疾病和癌症。此外，癌症和衰老一样，是一种复杂的疾病，是由各种遗传和表观遗传改变的积累引起的。最近，昼夜节律失调被确定为衰老和癌症发展的一个重要危险因素。天然化合物和草药因其在预防与年龄相关的疾病和抑制癌症进展方面的潜力而受到广泛关注。这些化合物具有抗氧化、抗炎、抗增殖、促凋亡、抗转移和抗血管生成作用，以及调节昼夜节律的作用。本综述探讨了与年龄相关的疾病、癌症以及特定天然化合物靶向这些疾病关键特征的潜力。
