School of Optometry & Vision Science, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
Neuropeptides. 2022 Oct;95:102266. doi: 10.1016/j.npep.2022.102266. Epub 2022 Jun 14.
Inflammation is the consequence of dry eye disease regardless of its etiology. Several injurious or harmless processes to the ocular surface neurons promote ocular surface neurogenic inflammation, leading to the vicious cycle of dry eye disease. These processes include the regular release of neuromediators during the conduction of ocular surface sensations, hyperosmolarity-induced ocular surface neuronal damage, neuro-regenerative activities, and neuronal-mediated dendritic cell activities. Neurogenic inflammation appears to be the main culprit, instigating the self-perpetuating inflammation observed in patients with dry eye disease.
炎症是干眼疾病的结果，无论其病因如何。眼表神经元的一些有害或无害过程会促进眼表神经原性炎症，导致干眼疾病的恶性循环。这些过程包括眼表感觉传导过程中神经递质的正常释放、高渗诱导的眼表神经元损伤、神经再生活动以及神经元介导的树突状细胞活性。神经原性炎症似乎是主要罪魁祸首，引发了干眼患者中观察到的自我持续炎症。
