Aragona Pasquale, Barabino Stefano, Di Zazzo Antonio, Giannaccare Giuseppe, Villani Edoardo, Aiello Francesco, Antoniazzi Elena, Bonini Stefano, Cantera Emilia, Carlini Gianpaolo, Chierego Chiara, Colabelli Rossella, Fasciani Romina, Franch Antonella, Gabbriellini Giovanna, Gagliano Caterina Maria Rita, Leonardi Andrea, Macrì Angelo, Mencucci Rita, Mosca Luigi, Orfeo Vincenzo, Pinna Antonio, Pocobelli Augusto, Protti Romolo, Rama Paolo, Rania Laura, Rechichi Miguel, Rubino Pierangela, Russo Andrea, Scorcia Vincenzo, Spadea Leopoldo, Trentadue Marco, Troisi Salvatore, Versura Piera, Rolando Maurizio
Department of Biomedical Sciences, Ophthalmology Clinic, University of Messina, Messina, Italy.
Ocular Surface and Dry Eye Center, Ospedale L. Sacco, University of Milan, Milan, Italy.
Ophthalmol Ther. 2025 May 28. doi: 10.1007/s40123-025-01161-8.
Dry eye disease (DED) is a common condition of the ocular surface that affects tens of millions of people worldwide. It is often characterized by decreased tear production or increased evaporation, resulting in a wide range of signs and symptoms. This review provides a comprehensive analysis of the literature related to DED, detailing causes, diagnostic tests, and medical management. Several mechanisms contribute to the maintenance of the physiological integrity of the ocular surface, and their dysfunction may result in noticeable symptoms. Accurate diagnosis is therefore essential, even when physiological function is only minimally impaired or no clear pathological signs are present. The review emphasizes the importance of addressing the underlying causes through a combination of treatment options, lifestyle changes, and enhanced communication between patients and healthcare providers to break the cycle of inflammation and tear instability. It aims to raise awareness among patients, healthcare professionals, and researchers regarding the diagnosis and treatment of DED, while also highlighting recent advancements and future challenges in its management.
干眼疾病(DED)是一种常见的眼表疾病,全球数以千万计的人受其影响。其特征通常为泪液分泌减少或蒸发增加,从而导致一系列体征和症状。本综述对与干眼疾病相关的文献进行了全面分析,详细阐述了病因、诊断测试及药物治疗。多种机制有助于维持眼表的生理完整性,其功能障碍可能导致明显症状。因此,即使生理功能仅有轻微受损或无明显病理体征,准确诊断也至关重要。该综述强调了通过综合治疗方案、生活方式改变以及加强患者与医疗服务提供者之间的沟通来解决根本原因以打破炎症和泪液不稳定循环的重要性。其目的是提高患者、医疗专业人员和研究人员对干眼疾病诊断和治疗的认识,同时突出其管理方面的最新进展和未来挑战。