谷胱甘肽 S-转移酶 M1、T1 和 P1 基因 Ile105Val 多态性与年龄相关性黄斑变性风险的关联：一项荟萃分析。
Association of GSTM1, GSTT1, and GSTP1 Ile105Val polymorphisms with risk of age-related macular degeneration: a meta-analysis.
机构信息
Department of Ophthalmology and Optometry, Nanchang University, Nanchang, Jiangxi Province, China.
Jiangxi Research Institute of Ophthalmology and Visual Sciences, Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Provincial Key Laboratory for Ophthalmology, Affiliated Eye Hospital of Nanchang University, Nanchang, Jiangxi, China.
出版信息
Ophthalmic Genet. 2022 Oct;43(5):615-621. doi: 10.1080/13816810.2022.2090009. Epub 2022 Jun 22.
BACKGROUND
This study determined to evaluate the association between glutathione S-transferase (GST) polymorphisms, namely, GSTM1 (rs1183423000, presence/absence), GSTT1 (rs1601993659, presence/absence), and GSTP1 Ile105Val (rs1695, A>G) polymorphisms, and AMD risk.
METHODS
We searched PubMed, Embase, and Web of Science databases from January 2000 to June 2021. The odds ratio (OR) and 95% confidence interval (95% CI) were used as effect sizes. Heterogeneity was assessed using the heterogeneity metric I.
RESULTS
Five relevant studies involving 875 patients with AMD and 966 healthy controls were included in this meta-analysis, four studies concerning GSTM1 null polymorphism, four studies regarding GSTT1 null polymorphism, and four studies on GSTP1 Ile105Val polymorphism. The GSTM1 null polymorphism, GSTT1 null polymorphism and GSTP1 Ile105Val polymorphism were not significantly associated with AMD risk (OR 1.13, 95% CI 0.73-1.75, p = 0.59; OR 1.05, 95% CI 0.81-1.36, p = 0.69; OR 1.20, 95% CI 0.97-1.47, p = 0.09, respectively). There was no association between the combined GSTM1 null genotype and GSTT1 null genotype and AMD risk (OR 1.16, 95% CI 0.42-3.17, p = 0.77). Subgroup analyses revealed that the GSTM1 null genotype was associated with an increased risk of AMD in the Turkish population (OR 1.67, 95% CI 1.13-2.47, p = 0.01) and the GSTM1 null genotype was associated with a decreased incidence of non-exudative AMD (OR 0.72, 95% CI 0.52-0.99, p = 0.01). There was no obvious risk of publication bias found.
CONCLUSIONS
This meta-analysis indicated that there were no significant associations between GSTM1, GSTT1, and GSTP1 Ile105Val polymorphisms and AMD risk.
背景
本研究旨在评估谷胱甘肽 S-转移酶（GST）多态性，即 GSTM1（rs1183423000，存在/缺失）、GSTT1（rs1601993659，存在/缺失）和 GSTP1 Ile105Val（rs1695，A>G）多态性与 AMD 风险之间的关联。
方法
我们检索了 2000 年 1 月至 2021 年 6 月期间的 PubMed、Embase 和 Web of Science 数据库。使用比值比（OR）和 95%置信区间（95%CI）作为效应量。使用异质性度量 I 评估异质性。
结果
本荟萃分析纳入了 5 项涉及 875 例 AMD 患者和 966 例健康对照的研究，其中 4 项研究涉及 GSTM1 缺失型多态性，4 项研究涉及 GSTT1 缺失型多态性，4 项研究涉及 GSTP1 Ile105Val 多态性。GSTM1 缺失型多态性、GSTT1 缺失型多态性和 GSTP1 Ile105Val 多态性与 AMD 风险无显著相关性（OR 1.13，95%CI 0.73-1.75，p=0.59；OR 1.05，95%CI 0.81-1.36，p=0.69；OR 1.20，95%CI 0.97-1.47，p=0.09）。联合 GSTM1 缺失基因型和 GSTT1 缺失基因型与 AMD 风险无关联（OR 1.16，95%CI 0.42-3.17，p=0.77）。亚组分析显示，GSTM1 缺失基因型与土耳其人群 AMD 风险增加相关（OR 1.67，95%CI 1.13-2.47，p=0.01），GSTM1 缺失基因型与非渗出性 AMD 发生率降低相关（OR 0.72，95%CI 0.52-0.99，p=0.01）。未发现明显的发表偏倚风险。
结论
本荟萃分析表明，GSTM1、GSTT1 和 GSTP1 Ile105Val 多态性与 AMD 风险之间无显著关联。
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