Wang Mo, Li Yu, Lin Lulu, Song Guijun, Deng Teng
Neurology Department No.1, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116023, China.
Capital Medical University, Beijing, 100068, China.
Mol Neurobiol. 2016 Mar;53(2):1355-1364. doi: 10.1007/s12035-015-9092-7. Epub 2015 Jan 30.
Published studies on the associations between glutathione S-transferase (GST) polymorphisms and Alzheimer's disease reported controversial findings. A meta-analysis of published studies was performed to assess the associations between polymorphisms of GSTM1, GSTT1 and GSTP1, and Alzheimer's disease. PubMed, Embase, and other databases were searched for case-control on the associations between polymorphisms of GSTM1, GSTT1 and GSTP1, and Alzheimer's disease. The odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the associations. Eleven articles were finally included into the meta-analysis, including eight studies on GSTM1 null genotype, six studies on GSTT1 null genotype, and six studies on GSTP1 Ile105Val polymorphism. Overall, GSTM1 null genotype was associated with increased risk of Alzheimer's disease (fixed effect OR = 1.34, 95% CI 1.10-1.64, P = 0.004). GSTT1 null genotype was not associated with risk of Alzheimer's disease (random effect OR = 1.15, 95% CI 0.68-1.92, P = 0.60). Besides, GSTP1 Ile105Val polymorphism was significantly associated with increased risk of Alzheimer's disease (Val vs Ile: OR = 1.45, 95% CI 1.05-1.99, P = 0.023; ValVal vs IleIle: OR = 1.87, 95% CI 1.30-2.69, P = 0.001; ValVal vs IleIle + IleVal: OR = 1.76, 95% CI 1.24-2.51, P = 0.002). No obvious risk of publication bias was observed in the meta-analysis. GSTM1 null genotype and GSTP1 Ile105Val polymorphism are associated with increased risk of Alzheimer's disease. More studies with large sample size are needed to validate the findings in the meta-analysis.
已发表的关于谷胱甘肽S-转移酶（GST）基因多态性与阿尔茨海默病之间关联的研究报告了相互矛盾的结果。进行了一项已发表研究的荟萃分析，以评估GSTM1、GSTT1和GSTP1基因多态性与阿尔茨海默病之间的关联。在PubMed、Embase和其他数据库中搜索关于GSTM1、GSTT1和GSTP1基因多态性与阿尔茨海默病之间关联的病例对照研究。采用比值比（OR）和95%置信区间（95%CI）来评估关联。最终有11篇文章纳入荟萃分析，其中包括8项关于GSTM1无效基因型的研究、6项关于GSTT1无效基因型的研究以及6项关于GSTP1 Ile105Val多态性的研究。总体而言，GSTM1无效基因型与阿尔茨海默病风险增加相关（固定效应OR = 1.34，95%CI 1.10 - 1.64，P = 0.004）。GSTT1无效基因型与阿尔茨海默病风险无关（随机效应OR = 1.15，95%CI 0.68 - 1.92，P = 0.60）。此外，GSTP1 Ile105Val多态性与阿尔茨海默病风险增加显著相关（Val vs Ile：OR = 1.45，95%CI 1.05 - 1.99，P = 0.023；ValVal vs IleIle：OR = 1.87，95%CI 1.30 - 2.69，P = 0.001；ValVal vs IleIle + IleVal：OR = 1.76，95%CI 1.24 - 2.51，P = 0.002）。荟萃分析中未观察到明显的发表偏倚风险。GSTM1无效基因型和GSTP1 Ile105Val多态性与阿尔茨海默病风险增加相关。需要更多大样本量的研究来验证荟萃分析中的结果。
