School of Mechanical Engineering, and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments, Southeast University, Nanjing, P. R. China.
Electrophoresis. 2022 Nov;43(21-22):2184-2194. doi: 10.1002/elps.202200077. Epub 2022 Aug 3.
Current three-dimensional micromixers for continuous flow reactions and nanoparticle synthesis are complex in structure and difficult to fabricate. This paper investigates the design, fabrication, and characterization of a novel micromixer that uses a simple spatial Tesla valve design to achieve efficient mixing of multiple solutions. The flow characteristics and mixing efficiencies of our Tesla valve micromixer are investigated using a combination of numerical simulations and experiments. The results show that in a wide range of flow rates, viscoelastic solutions with different concentrations can be well mixed in our micromixer. Finally, experiments on the synthesis of chitosan nanoparticles are conducted to verify the practicability of our micromixer. Compared with nanoparticles prepared by conventional magnetic stirring, the size of nanoparticles prepared by micromixing is smaller and the distribution is more uniform. Therefore, our Tesla valve micromixer has significant advantages and implications for mixing chemical and biological reactions.
目前用于连续流反应和纳米粒子合成的三维微混合器结构复杂，制造困难。本文研究了一种新型微混合器的设计、制造和特性，该混合器使用简单的空间特斯拉阀设计来实现多种溶液的有效混合。我们使用数值模拟和实验相结合的方法研究了我们的特斯拉阀微混合器的流动特性和混合效率。结果表明，在较宽的流速范围内，我们的微混合器可以很好地混合不同浓度的粘弹性溶液。最后，进行了壳聚糖纳米粒子合成实验，以验证我们的微混合器的实用性。与传统磁力搅拌制备的纳米粒子相比，微混合制备的纳米粒子尺寸更小，分布更均匀。因此，我们的特斯拉阀微混合器在混合化学和生物反应方面具有显著的优势和意义。
