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具有单向流动特性的基于特斯拉阀的柔性微混合芯片。

Tesla Valve-Based Flexible Microhybrid Chip with Unidirectional Flow Properties.

作者信息

Wang Junyao, Cui Bowen, Liu Huan, Chen Xingyu, Li Yunpeng, Wang Rui, Lang Tianhong, Yang Hanbo, Pan Hongxu, Quan Jingran, Chen Yansong, Xu Jianxin, Liu Yahao

机构信息

Northeast Electric Power University, Jilin 132012, China.

出版信息

ACS Omega. 2022 Aug 28;7(36):31744-31755. doi: 10.1021/acsomega.2c02075. eCollection 2022 Sep 13.

DOI:10.1021/acsomega.2c02075
PMID:36120004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9475615/
Abstract

Flexible microfluidic chips have good application prospects in situations with easy bending and complex curvature. An important factor affecting the flexible microfluidic chip is its structural complexity. For example, the hybrid chip includes flow channels, mixing chambers, and one-way valves. How to achieve the same function with as few structures as possible has become an important research topic at present. In this paper, a Tesla valve micromixer with unidirectional flow characteristics is presented. A passive laminar flow Tesla valve micromixer is fabricated through 3D printing technology and limonene dissolution method. The main process is as follows: First of all, high impact polystyrene (HIPS) material was employed to make the Tesla valve channel mold. Second, the channel mold was dissolved in the limonene solvent. The mold of Tesla micromixer is made of HIPS material, the mixing experiment displace that the Tesla valve micromixer is characterized by unidirectional flow compared with the common T-shaped planar channel. At the same time, the 5-AAC Tesla valve micromixer can increase the mixing efficiency to 87%. By using four different groove structures and different flow rates of the mixing effect experiment, the conclusion is that the mixing efficiency of the 6-AAC Tesla valve micromixer is up to 0.89 when the flow rate is 2 mL/min. The results manifest that the Tesla valve structure can effectively improve the mixing efficiency.

摘要

柔性微流控芯片在易于弯曲和曲率复杂的情况下具有良好的应用前景。影响柔性微流控芯片的一个重要因素是其结构复杂性。例如，混合芯片包括流道、混合腔和单向阀。如何用尽可能少的结构实现相同的功能已成为当前一个重要的研究课题。本文提出了一种具有单向流动特性的特斯拉阀微混合器。通过3D打印技术和柠檬烯溶解法制造了一种被动层流特斯拉阀微混合器。主要过程如下：首先，采用高抗冲聚苯乙烯（HIPS）材料制作特斯拉阀通道模具。其次，将通道模具溶解在柠檬烯溶剂中。特斯拉微混合器的模具由HIPS材料制成，混合实验表明，与普通T形平面通道相比，特斯拉阀微混合器具有单向流动的特点。同时，5-AAC特斯拉阀微混合器可将混合效率提高到87%。通过使用四种不同的槽结构和不同流速进行混合效果实验，得出当流速为2 mL/min时，6-AAC特斯拉阀微混合器的混合效率高达0.89的结论。结果表明，特斯拉阀结构可以有效提高混合效率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/17898087d5ed/ao2c02075_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/9424577a4c59/ao2c02075_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/26085e69d958/ao2c02075_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/76968c75147b/ao2c02075_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/89dc1118718d/ao2c02075_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/b4478d91dda3/ao2c02075_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/7b9b1729f799/ao2c02075_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/385f12ebb461/ao2c02075_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/1c75c29768be/ao2c02075_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/086abf927fd5/ao2c02075_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/17898087d5ed/ao2c02075_0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/9424577a4c59/ao2c02075_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/26085e69d958/ao2c02075_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/76968c75147b/ao2c02075_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/89dc1118718d/ao2c02075_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/b4478d91dda3/ao2c02075_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/7b9b1729f799/ao2c02075_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/385f12ebb461/ao2c02075_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/1c75c29768be/ao2c02075_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/086abf927fd5/ao2c02075_0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4eec/9475615/17898087d5ed/ao2c02075_0011.jpg

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无阀微流控蠕动泵送方法。
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