一种易于制造的三维螺纹双纽线形状的微混合器，适用于广泛的流速范围。
An easily fabricated three-dimensional threaded lemniscate-shaped micromixer for a wide range of flow rates.
作者信息
Rafeie Mehdi, Welleweerd Marcel, Hassanzadeh-Barforoushi Amin, Asadnia Mohsen, Olthuis Wouter, Ebrahimi Warkiani Majid
机构信息
BIOS-Lab on a Chip group, MESA+ Institute for Nanotechnology and MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.
School of Mechanical and Manufacturing Engineering, University of New South Wales, Sydney, NSW 2052, Australia.
出版信息
Biomicrofluidics. 2017 Jan 30;11(1):014108. doi: 10.1063/1.4974904. eCollection 2017 Jan.
Mixing fluid samples or reactants is a paramount function in the fields of micro total analysis system (μTAS) and microchemical processing. However, rapid and efficient fluid mixing is difficult to achieve inside microchannels because of the difficulty of diffusive mass transfer in the laminar regime of the typical microfluidic flows. It has been well recorded that the mixing efficiency can be boosted by migrating from two-dimensional (2D) to three-dimensional (3D) geometries. Although several 3D chaotic mixers have been designed, most of them offer a high mixing efficiency only in a very limited range of Reynolds numbers (). In this work, we developed a 3D fine-threaded lemniscate-shaped micromixer whose maximum numerical and empirical efficiency is around 97% and 93%, respectively, and maintains its high performance (i.e., >90%) over a wide range of 1 < < 1000 which meets the requirements of both the μTAS and microchemical process applications. The 3D micromixer was designed based on two distinct mixing strategies, namely, the inducing of chaotic advection by the presence of Dean flow and diffusive mixing through thread-like grooves around the curved body of the mixers. First, a set of numerical simulations was performed to study the physics of the flow and to determine the essential geometrical parameters of the mixers. Second, a simple and cost-effective method was exploited to fabricate the convoluted structure of the micromixers through the removal of a 3D-printed wax structure from a block of cured polydimethylsiloxane. Finally, the fabricated mixers with different threads were tested using a fluorescent microscope demonstrating a good agreement with the results of the numerical simulation. We envisage that the strategy used in this work would expand the scope of the micromixer technology by broadening the range of efficient working flow rate and providing an easy way to the fabrication of 3D convoluted microstructures.
混合流体样本或反应物是微全分析系统（μTAS）和微化学处理领域的一项至关重要的功能。然而，由于在典型微流体流动的层流状态下扩散传质困难，在微通道内实现快速高效的流体混合颇具挑战。已有充分记录表明，从二维（2D）几何结构转变为三维（3D）几何结构可提高混合效率。尽管已设计出多种三维混沌混合器，但其中大多数仅在非常有限的雷诺数范围内具有较高的混合效率。在这项工作中，我们开发了一种三维细螺纹lemniscate形微混合器，其最大数值效率和经验效率分别约为97%和93%，并在1＜ ＜1000的宽范围内保持其高性能（即＞90%），满足了μTAS和微化学过程应用的要求。该三维微混合器基于两种不同的混合策略进行设计，即通过Dean流诱导混沌平流以及通过混合器弯曲体周围的丝状凹槽进行扩散混合。首先，进行了一组数值模拟，以研究流动物理特性并确定混合器的基本几何参数。其次，采用一种简单且经济高效的方法，通过从固化的聚二甲基硅氧烷块中去除3D打印的蜡结构来制造微混合器的复杂结构。最后，使用荧光显微镜对制造的具有不同螺纹的混合器进行测试，结果与数值模拟结果吻合良好。我们设想，这项工作中使用的策略将通过拓宽高效工作流速范围并提供一种制造三维复杂微结构的简便方法来扩大微混合器技术的范围。
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