Gómez-González Jacobo, Martínez-Castro Laura, Tolosa-Barrilero Juan, Alcalde-Ordóñez Ana, Learte-Aymamí Soraya, Mascareñas José L, García-Martínez Joaquín C, Martínez-Costas José, Maréchal Jean-Didier, Vázquez López Miguel, Vázquez M Eugenio
Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Spain.
Insilichem, Departament de Química, Universitat Autònoma de Barcelona, 08193 Cerdanyola, Spain.
Chem Commun (Camb). 2022 Jul 12;58(56):7769-7772. doi: 10.1039/d2cc02874c.
Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.
非经典DNA结构，特别是在DNA复制过程中短暂形成的三向连接（3WJs），最近已成为有前景的化疗靶点。在此，我们描述了一种靶向3WJs的新方法，该方法依赖于连接在具有三重对称性且可产生荧光的1,3,5-三苯乙烯基苯核心上的三条AT-钩肽对富含A/T的双链DNA分支进行协同且序列选择性识别。
