Lelouche Sorraya Najma Kinza, Albentosa-González Laura, Clemente-Casares Pilar, Biglione Catalina, Rodríguez-Diéguez Antonio, Tolosa Barrilero Juan, García-Martínez Joaquín Calixto, Horcajada Patricia
Advanced Porous Materials Unit, IMDEA Energy Institute, Av. Ramón de la Sagra 3, Mostoles, 28935 Madrid, Spain.
Escuela Internacional de Doctorado, Universidad Rey Juan Carlos, c/ Tulipan, s/n, Mostoles, 28933 Madrid, Spain.
Nanomaterials (Basel). 2023 Aug 9;13(16):2294. doi: 10.3390/nano13162294.
Metal-organic frameworks (MOFs) are highly versatile materials. Here, two novel MOFs, branded as IEF-23 and IEF-24 and based on an antibacterial tricarboxylate linker and zinc or copper cations, and holding antibacterial properties, are presented. The materials were synthesized by the solvothermal route and fully characterized. The antibacterial activity of IEF-23 and IEF-24 was investigated against and via the agar diffusion method. These bacteria are some of the most broadly propagated pathogens and are more prone to the development of antibacterial resistance. As such, they represent an archetype to evaluate the efficiency of novel antibacterial treatments. MOFs were active against both strains, exhibiting higher activity against . Thus, the potential of the developed MOFs as antibacterial agents was proved.
金属有机框架（MOF）是用途极为广泛的材料。本文展示了两种新型MOF，分别命名为IEF - 23和IEF - 24，它们基于一种抗菌三羧酸盐连接体与锌或铜阳离子，具有抗菌性能。这些材料通过溶剂热法合成并进行了全面表征。采用琼脂扩散法研究了IEF - 23和IEF - 24对[具体细菌1]和[具体细菌2]的抗菌活性。这些细菌是传播最为广泛的一些病原体，且更容易产生抗菌耐药性。因此，它们是评估新型抗菌治疗效果的典型代表。MOF对这两种菌株均有活性，对[具体细菌1]表现出更高的活性。由此证明了所开发的MOF作为抗菌剂的潜力。
