Emerg Infect Dis. 2022 Jul;28(7):1313-1320. doi: 10.3201/eid2807.212221.
We combined American Community Survey data with age-specific Trypanosoma cruzi prevalence derived from US surveys and World Health Organization reports to yield estimates of Chagas disease in the United States, which we mapped at the local level. In addition, we used blood donor data to estimate the relative prevalence of autochthonous T. cruzi infection. Our estimates indicate that 288,000 infected persons, including 57,000 Chagas cardiomyopathy patients and 43,000 infected reproductive-age women, currently live in the United States; 22-108 congenital infections occur annually. We estimated ≈10,000 prevalent cases of locally acquired T. cruzi infection. Mapping shows marked geographic heterogeneity of T. cruzi prevalence and illness. Reliable demographic and geographic data are key to guiding prevention and management of Chagas disease. Population-based surveys in high prevalence areas could improve the evidence base for future estimates. Knowledge of the demographics and geographic distribution of affected persons may aid practitioners in recognizing Chagas disease.
我们将美国社区调查数据与源自美国调查和世界卫生组织报告的特定年龄的克氏锥虫流行率相结合，得出了美国恰加斯病的估计数，并在地方一级进行了绘制。此外，我们还利用献血者数据估计了本地感染克氏锥虫的相对流行率。我们的估计表明，目前有 28.8 万名感染者，包括 5.7 万名恰加斯心肌病患者和 4.3 万名感染性育龄妇女；每年有 22-108 例先天性感染。我们估计约有 1 万例本地获得性克氏锥虫感染的现患病例。制图显示克氏锥虫流行率和疾病存在明显的地理异质性。可靠的人口统计和地理数据是指导恰加斯病预防和管理的关键。在高流行地区进行基于人群的调查可以为未来的估计提供更好的证据基础。了解受影响者的人口统计学和地理分布情况可能有助于临床医生识别恰加斯病。
