Department of Epidemiology and Biostatistics Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA.
Division of Infectious Diseases & Global Medicine, Department of Medicine, University of Florida, Gainesville, Florida, USA.
Transfusion. 2022 Sep;62(9):1808-1817. doi: 10.1111/trf.17026. Epub 2022 Jul 27.
Chagas disease is a parasitic infection that can insidiously cause non-ischemic cardiomyopathy. Given the largely silent nature of this progressive disease, asymptomatic blood donors pose potential blood transfusion risk. Blood donation screening has become an unintentional form of Chagas disease surveillance, with thousands of new cases identified since national surveillance was initiated in 2007.
We recruited T. cruzi-positive blood donors identified from California and Arizona blood centers for confirmatory blood screening and assessment of lifetime infection risk.
Among eight suspected cases, we identified four confirmed US autochthonous infections. The current manuscript details the transmission sources, healthcare-seeking behaviors post-blood donation resulting, and clinical course of disease among persons without any history of travel to endemic Latin American countries.
This manuscript presents four additional US-acquired Chagas disease cases and identifies an opportunity for blood centers to assist in confronting barriers surrounding Chagas disease in the US.
恰加斯病是一种寄生虫感染，可悄然导致非缺血性心肌病。鉴于这种进行性疾病在很大程度上是无症状的，无症状的献血者可能带来输血传播的风险。自 2007 年开始全国性监测以来，献血筛查已成为一种无意的恰加斯病监测形式，发现了数千例新病例。
我们招募了来自加利福尼亚州和亚利桑那州血液中心的 T. cruzi 阳性献血者进行确认性血液筛查和终生感染风险评估。
在 8 例疑似病例中，我们确定了 4 例美国本土感染的确诊病例。本文详细介绍了传播源、献血后寻求医疗服务的行为以及没有前往拉丁美洲流行国家旅行史的患者的疾病临床过程。
本文介绍了另外 4 例美国获得性恰加斯病病例，并确定了血液中心有机会协助解决美国恰加斯病面临的障碍。
