Ryan P C, Fitzpatrick J M
J Urol. 1987 May;137(5):1034-8. doi: 10.1016/s0022-5347(17)44354-0.
An experimental model of ureteric obstruction should be accurate and persistent, and allow variation of the degree of obstruction. A model was tested in 28 dogs consisting of insertion of an obstructing stent into the left ureter, and the degree of obstruction was varied by altering the internal diameter of the stents. The effects of such an obstruction on the following features were studied: renal intrapelvic pressure, intravenous urography, creatinine clearance, vascular casts, and both gross and histological examination. The procedure was well tolerated and caused a persistent, unchanging degree of partial ureteric obstruction. Pathological changes of obstructive uropathy were produced. This model can be used for further pathophysiological studies.
输尿管梗阻的实验模型应准确且持久，并能改变梗阻程度。在28只犬身上测试了一种模型，该模型是在左输尿管内插入阻塞支架，并通过改变支架内径来改变梗阻程度。研究了这种梗阻对以下特征的影响：肾盂内压、静脉肾盂造影、肌酐清除率、血管铸型以及大体和组织学检查。该手术耐受性良好，导致了持续不变的部分输尿管梗阻程度。产生了梗阻性肾病的病理变化。该模型可用于进一步的病理生理学研究。
