Center for Translational Medicine and Shanghai, Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Department of Gerontology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Proteomics. 2022 Aug;22(15-16):e2100324. doi: 10.1002/pmic.202100324. Epub 2022 Jul 13.
The burden of neurological and neuropsychiatric disorders continues to grow with significant impacts on human health and social economy worldwide. Increasing clinical and preclinical evidences have implicated that bile acids (BAs) are involved in the onset and progression of neurological and neuropsychiatric diseases. Here, we summarized recent studies of BAs in three types of highly prevalent brain disorders, depression, Alzheimer's disease, and stroke. The shared and specific BA profiles were explored and potential markers associated with disease development and progression were summarized. The mechanistic roles of BAs were reviewed with focuses on inflammation, gut-brain-microbiota axis, cellular apoptosis. We also discussed future perspectives for the prevention and treatment of neurological and neuropsychiatric disorders by targeting BAs and related molecules and gut microbiota. Our understanding of BAs and their roles in brain disorders is still evolving. A large number of questions still need to be addressed on the emerging crosstalk among central, peripheral, intestine, and their contribution to brain and mental health.
神经和神经精神疾病的负担持续增加，对全球人类健康和社会经济造成重大影响。越来越多的临床前和临床证据表明，胆汁酸（BAs）参与了神经和神经精神疾病的发生和发展。在这里，我们总结了 BAs 在三种高发性脑疾病（抑郁症、阿尔茨海默病和中风）中的最新研究。探讨了共享和特定的 BA 特征，并总结了与疾病发展和进展相关的潜在标志物。我们综述了 BAs 的作用机制，重点关注炎症、肠-脑-微生物群轴、细胞凋亡。我们还讨论了通过靶向 BAs 及其相关分子和肠道微生物群来预防和治疗神经和神经精神疾病的未来展望。我们对 BAs 及其在脑疾病中的作用的理解仍在不断发展。中枢、外周、肠道之间新兴的相互作用及其对大脑和心理健康的贡献仍有大量问题需要解决。
