女性空乘人员的乳腺癌与职业暴露的关系：系统评价和荟萃分析。
Breast Cancer Among Female Flight Attendants and the Role of the Occupational Exposures: A Systematic Review and Meta-analysis.
机构信息
From the Chair of Epidemiology, Department of Sport and Health Sciences, Technical University of Munich, Munich, Bavaria, Germany.
出版信息
J Occup Environ Med. 2022 Oct 1;64(10):822-830. doi: 10.1097/JOM.0000000000002606. Epub 2022 Jun 21.
OBJECTIVE
We conducted a systematic review and meta-analysis to investigate occupational exposures and their role in breast cancer (BC) risk among female flight attendants (FFAs).
METHODS
We systematically searched PubMed and EMBASE and included all observational studies reporting on the outcome BC incidence among FFAs. The exposures of interest were cosmic radiation and circadian rhythm disruption. Study quality was assessed using the Newcastle-Ottawa Scale.
RESULTS
Nine studies met the inclusion criteria, of which four were included in the meta-analysis for BC incidence (pooled standardized incidence ratio, 1.43; 95% confidence interval, 1.32 to 1.54). Three studies suggested a possible association between BC and cosmic radiation, whereas none found an association with circadian rhythm disruption.
CONCLUSION
Neither exposure to cosmic radiation nor circadian rhythm disruption seems to explain the elevated risk of BC among flight attendants. Further studies reporting individual information on occupational exposures are needed.
目的
我们进行了一项系统回顾和荟萃分析，旨在研究女性空乘人员（FFAs）的职业暴露及其在乳腺癌（BC）风险中的作用。
方法
我们系统地检索了 PubMed 和 EMBASE，并纳入了所有报告 FFAs 中 BC 发病率结局的观察性研究。感兴趣的暴露因素是宇宙辐射和昼夜节律紊乱。使用纽卡斯尔-渥太华量表评估研究质量。
结果
符合纳入标准的研究有 9 项，其中 4 项纳入了 BC 发病率的荟萃分析（合并标准化发病率比，1.43；95%置信区间，1.32 至 1.54）。有 3 项研究提示 BC 与宇宙辐射之间可能存在关联，而没有研究发现与昼夜节律紊乱有关。
结论
宇宙辐射暴露或昼夜节律紊乱似乎都不能解释空乘人员中 BC 风险的增加。需要进一步研究报告职业暴露的个体信息。
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