Department of Mental Health, Hospital Universitari Mútua de Terrassa, Terrassa, Spain.
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, Madrid, Spain.
Arch Womens Ment Health. 2022 Aug;25(4):693-703. doi: 10.1007/s00737-022-01241-9. Epub 2022 Jun 23.
The aim of our study was to examine whether there are sex-based differences in the relationship between personality traits and hypothalamic-pituitary-adrenal (HPA) axis measures. A total of 106 healthy volunteers (56.6% women; age: 48.0 ± 15.8 years) were studied. The revised temperament and character inventory (TCI-R) and the Childhood Trauma Questionnaire (CTQ) were administered. HPA axis function was assessed using three dynamic measures: the cortisol awakening response (CAR), the diurnal cortisol slope, and the cortisol suppression ratio with 0.25 mg of dexamethasone (DSTR). Female sex was associated with an increased CAR and a more flattened diurnal cortisol slope, although a negative significant interaction between harm avoidance and female sex was found. Regarding the DSTR, perseverance was associated with increased cortisol suppression after dexamethasone; sex did not affect this association. Our study suggests that the relationship between specific personality traits (harm avoidance) and HPA axis measures (CAR, diurnal slope) differs according to sex.
我们的研究目的是检验个性特征与下丘脑-垂体-肾上腺（HPA）轴之间的关系是否存在性别差异。共有 106 名健康志愿者（56.6%为女性；年龄：48.0±15.8 岁）参与了研究。采用修订后的气质与性格量表（TCI-R）和童年创伤问卷（CTQ）进行评估。使用三种动态测量方法评估 HPA 轴功能：皮质醇觉醒反应（CAR）、日间皮质醇斜率和 0.25mg 地塞米松的皮质醇抑制比（DSTR）。女性性别与 CAR 增加和日间皮质醇斜率更平坦相关，尽管发现了回避和女性性别之间的负显著交互作用。关于 DSTR，坚持与地塞米松后皮质醇抑制增加有关；性别并不影响这种关联。我们的研究表明，特定个性特征（回避）与 HPA 轴测量值（CAR、日间斜率）之间的关系因性别而异。
