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毛霉菌病与显微镜下多血管炎并存:诊断与治疗挑战

Coexistence of Mucormycosis and Granulomatosis With Polyangiitis: A Diagnostic and Therapeutic Challenge.

作者信息

Sanku Koushik, Youssef Dima

机构信息

Internal Medicine, East Tennessee State University - Quillen College of Medicine, Johnson City, USA.

Hematology and Oncology, Brooklyn Cancer Care, New York City, USA.

出版信息

Cureus. 2022 May 18;14(5):e25124. doi: 10.7759/cureus.25124. eCollection 2022 May.

Abstract

Mucormycosis is a destructive, necrotizing, and potentially fatal fungal disease that usually affects immunocompromised or diabetic patients. Granulomatosis with polyangiitis (GPA), previously known as Wegener's granulomatosis is a rare, aseptic necrotizing, granulomatous vasculitis affecting small- to medium-sized vessels, resulting in systemic manifestations. Here, we present a case of a 46-year-old gentleman with overlapping features of mucormycosis and GPA, that was successfully treated with isavuconazole monotherapy.

摘要

毛霉病是一种具有破坏性、坏死性且可能致命的真菌疾病,通常影响免疫功能低下或糖尿病患者。肉芽肿性多血管炎(GPA),以前称为韦格纳肉芽肿,是一种罕见的无菌性坏死性肉芽肿性血管炎,影响中小血管,导致全身表现。在此,我们报告一例46岁男性患者,具有毛霉病和GPA的重叠特征,经艾沙康唑单药治疗成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bbc/9205389/ac61c479d69e/cureus-0014-00000025124-i01.jpg

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