Sutedja Eva Krishna, Rizqandaru Trustia, Ruchiatan Kartika, Sutedja Endang
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.
Int Med Case Rep J. 2022 Jun 15;15:293-298. doi: 10.2147/IMCRJ.S369726. eCollection 2022.
Cutaneous metastases (CM) are neoplastic lesions of the skin originating from a primary tumor elsewhere. CM originating from primary thymic carcinoma is rare, and its incidence remains uncertain. A case of CM from thymic carcinoma in a 57-year-old man was reported. The patient complained about lumps on the skin of the chest, right shoulder and neck that appeared eleven months before the diagnosis of thymic carcinoma was established. Physical examination revealed tumors on the chest, right shoulder and neck. Histopathological examination results were consistent with CM. An immunohistochemical (IHC) examination was performed to determine the primary tumor, with a positive result for CK7. The diagnosis of thymic carcinoma was established based on the results of enhanced chest CT-scan and immunohistochemistry on lymph node biopsies. The patient was treated with a chemotherapy regimen of cyclophosphamide, doxorubicin, and carboplatin scheduled for six cycles. However, the patient did not survive his third cycle of chemotherapy. Establishing the diagnosis and managing CM are challenging for clinicians. This requires careful historical and physical examination, supported by histopathological examination and specific immunohistochemical marker in accordance with the suspected tumor.
皮肤转移瘤（CM）是起源于其他部位原发性肿瘤的皮肤肿瘤性病变。源自原发性胸腺癌的CM罕见，其发病率仍不确定。本文报告了一例57岁男性胸腺癌皮肤转移瘤病例。该患者在胸腺癌确诊前11个月就出现了胸部、右肩和颈部皮肤肿块。体格检查发现胸部、右肩和颈部有肿瘤。组织病理学检查结果与CM相符。进行了免疫组织化学（IHC）检查以确定原发性肿瘤，CK7结果呈阳性。基于增强胸部CT扫描结果和淋巴结活检的免疫组织化学结果确诊为胸腺癌。该患者接受了环磷酰胺、阿霉素和卡铂的化疗方案，计划进行六个周期。然而，患者在第三个化疗周期时死亡。对临床医生来说，CM的诊断和管理具有挑战性。这需要仔细的病史和体格检查，并辅以组织病理学检查以及根据疑似肿瘤使用特定的免疫组织化学标志物。
