Sofian Masoomeh, Khansarinejad Behzad, Ghaznavi-Rad Ehsanollah, Shokoohi Farzaneh, Mazaherpour Hossein, Farmani Farzane, Sadat Larijani Mona, Pakpour Leila, Ramezani Amitis
Infectious Disease Research Center (IDRC), Arak University of Medical Science, Arak, Iran.
Department of Microbiology and Immunology, Arak University of Medical Sciences, Arak, Iran.
Interdiscip Perspect Infect Dis. 2022 Jun 12;2022:1411106. doi: 10.1155/2022/1411106. eCollection 2022.
According to the contagious ability of the new virus, SARS-CoV-2, characterization of viral shedding duration in the period of infection is highly valuable in terms of providing quarantine guidelines and isolation policies. Therefore, we aimed at viral shedding determination in 58 COVID-19 confirmed Iranian subjects in different stages.
58 COVID-19 confirmed Iranian subjects including 21 outpatients and 37 inpatients were investigated. The analytical data and clinical properties were documented in the standard questionnaire. The RT-PCR tests were done two and three weeks after the symptoms initiation.
Viral eradication occurred in 44.8% two weeks after illness initiation whereas in 71% who achieved a negative PCR test in the third week. Moreover, prolonged viral shedding was observed in hospitalized cases in comparison to outpatients. Almost 30% of patients continued viral shedding three weeks after disease initiation.
A longer duration of viral shedding in hospitalized cases rather than outpatients was observed in this study. The results similar to other investigations call into question if the current policies are enough to prevent the viral spread or not. This study should be done on a larger sample to provide an appropriate time in isolation policy.
根据新型冠状病毒SARS-CoV-2的传播能力，确定感染期间病毒脱落持续时间对于制定隔离指南和隔离政策具有重要价值。因此，我们旨在确定58名确诊为COVID-19的不同阶段伊朗患者的病毒脱落情况。
对58名确诊为COVID-19的伊朗患者进行了调查，其中包括21名门诊患者和37名住院患者。分析数据和临床特征记录在标准问卷中。在症状出现后两周和三周进行逆转录聚合酶链反应（RT-PCR）检测。
发病后两周，44.8%的患者病毒清除，而在第三周PCR检测呈阴性的患者中这一比例为71%。此外，与门诊患者相比，住院患者的病毒脱落时间延长。近30%的患者在发病三周后仍有病毒脱落。
本研究观察到住院患者的病毒脱落持续时间比门诊患者更长。与其他研究结果相似，这引发了对当前政策是否足以防止病毒传播的质疑。本研究应扩大样本量，以确定合适的隔离时间。
