结直肠癌患者血清组织蛋白酶S水平的评估。
Evaluation of serum levels of cathepsin S among colorectal cancer patients.
作者信息
Ghanadi Koroush, Ashorzadeh Saber, Aliyepoor Asghar, Anbari Khatereh
机构信息
Hepatitis Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.
出版信息
Ann Med Surg (Lond). 2022 May 24;78:103831. doi: 10.1016/j.amsu.2022.103831. eCollection 2022 Jun.
OBJECTIVE
Colorectal cancer is the third most common cancer worldwide. Cathepsins are protease that are known to be involved in cancer progression and metastasis. The aim of this study is to evaluate the levels of serum cathepsin S in patients and control subjects and its effects on the prognosis of the cancer.
METHODS
In this case-control study, colorectal cancer patients referred to our gastroenterology clinic were included. The control group consisted of healthy individuals. Cathepsin S levels were analyzed in these patients and the check list consisting of demographic data, cancer stage, colonoscopy findings, CEA marker and cathepsin S levels were recorded.
RESULTS
Of 80 patients and healthy controls included in the study, age, gender and BMI were not significantly different among the two groups, p = 0.265, p = 0.752 and p = 0.2, respectively. Cathepsin S levels were significantly greater in-patient group p < 0.001 and was significantly correlated with the stage of the tumor. CEA marker was also linear related with the increased levels of cathepsin S, p < 0.001.
CONCLUSION
Our study concluded that cathepsin S is elevated in the cancer patients and can be a significant marker for the prognosis of colorectal cancer.
目的
结直肠癌是全球第三大常见癌症。组织蛋白酶是已知参与癌症进展和转移的蛋白酶。本研究的目的是评估患者和对照受试者血清组织蛋白酶S的水平及其对癌症预后的影响。
方法
在这项病例对照研究中，纳入了转诊至我们胃肠病学诊所的结直肠癌患者。对照组由健康个体组成。分析这些患者的组织蛋白酶S水平，并记录由人口统计学数据、癌症分期、结肠镜检查结果、癌胚抗原（CEA）标志物和组织蛋白酶S水平组成的检查表。
结果
在纳入研究的80例患者和健康对照中，两组之间的年龄、性别和体重指数（BMI）无显著差异，分别为p = 0.265、p = 0.752和p = 0.2。患者组的组织蛋白酶S水平显著更高，p < 0.001，且与肿瘤分期显著相关。CEA标志物也与组织蛋白酶S水平的升高呈线性相关，p < 0.001。
结论
我们的研究得出结论，组织蛋白酶S在癌症患者中升高，并且可能是结直肠癌预后的一个重要标志物。
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