Liusov V A, Kharchenko V I, Mart'ianova I I, Shcheplikova T M, Evsikov E M
Kardiologiia. 1987 Feb;27(2):71-6.
Hypotensive activity of labetalol therapy alone or in combination with the diuretic agent oxodolin or with low-sodium diet (about 110 mmol/day) and potassium cooking salt substitute "Sanasol" (60% sodium chloride, ammonium chloride, calcium gluconate, magnesium asparaginate, etc.) was studied in 67 patients with second- or third-stage essential hypertension and 14 patients with nephrogenic hypertension. Central hemodynamic changes were assessed by means of radiocardiography and tetrapolar rheography. Combined treatment had better hypotensive effect in moderate and severe hypertension (diastolic arterial BP above 110 mm Hg). The diuretic-labetalol combination made possible a 25-45% reduction in the adrenoblocker dose. The effect of combined hypotensive treatment was similar in patients with different central hemodynamic types. Low-sodium diet with potassium substitute was well tolerated by the patients.
对67例二期或三期原发性高血压患者和14例肾性高血压患者，研究了拉贝洛尔单独治疗、或与利尿剂奥索多林联合治疗、或与低钠饮食（约110 mmol/天）及钾烹饪盐替代品“Sanasol”（含60%氯化钠、氯化铵、葡萄糖酸钙、天冬氨酸镁等）联合治疗的降压活性。通过放射心动图和四极血流图评估中心血流动力学变化。联合治疗在中度和重度高血压（舒张压高于110 mmHg）中具有更好的降压效果。利尿剂-拉贝洛尔联合使用可使肾上腺阻滞剂剂量减少25%-45%。不同中心血流动力学类型的患者，联合降压治疗的效果相似。患者对含钾替代品的低钠饮食耐受性良好。
